Prion Diseases Essay -- Medical Prions Disease TSE

Prion Diseases Abstract Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that are thought to be caused by the misfolding of prion proteins. Prions are able to replicate in the absence of nucleic acids. TSEs include: scrapie, bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler-Scheinker disease, and Fatal Familial Insomnia. They can affect many different animals, including humans. Currently, there are no ways to diagnose, treat, or cure TSEs, as much more research is needed before these diseases are completely understood. 1. Overview Prions are a type of protein found naturally in the brain and other regions of the central nervous system. The diseases associated with prions are collectively known as transmissible spongiform encephalopathies (TSEs). â€Å"Transmissible† refers to their potentially infectious nature, and â€Å"spongiform encephalopathies† indicates the microscopic sponge-like deterioration of the brain caused by the progression of the disorders. While these fatal neurodegenerative diseases exhibit different clinical symptoms, have different incubation periods, and even target different areas of the brain, they do share a number of characteristics. They occur in both animals and humans. During a silent incubation period, there are no detectable signs of the disease, although depending on the specific disease, the length of the incubation period can â€Å"vary from a few weeks to up to 40 [years]† (Baker & Ridley, 1996, 1). Due to their unique method of propagation (which will be addressed later), TSEs present a seeming paradox in that â€Å"inherited cases give rise to a disease that is transmissible but acquired cases do not produce heritable diseases† (Baker & Rid... ...(Soto, 2006, 105). 15. Conclusion On a closing note, prion research is significant not only for possible breakthroughs in understanding TSEs, but because of the vast implications the very concept of prions holds for the entire field of biology. As the first substance discovered that can replicate in the absence of nucleic acids, prions defy one of the most central biological doctrines. The similarities between TSEs and dementia disorders like Alzheimer’s disease and â€Å"findings of proteins with a prion-like behavior in yeast and other fungi† (Soto, 2006, 143) suggest that prions and proteins like them may be much more common than ever expected (Soto, 2006, 154). 10 Bibliography Baker, Harry F., & Ridley, Rosalind M. (1996). Prion Diseases. Totowa, New Jersey: Humana Press. Soto, Claudio. (2006). Prions: The New Biology of Proteins. Boca Raton, Florida: CRC Press.

Character analysis of The Scarlett Letter

Character Analysis Essay. The Scarlet Letter â€Å"Grief does not change you, Hazel. It reveals you. † These are the words of John Green in The Fault in Our stars. This also applies somewhat to Arthur Timescale in The Scarlet Letter. Grief does not change him but his reaction to grief changes throughout the book. Reverend Timescale changes In the beginning, middle and end of the book. Rev Timescale Is religiously strict and Is well trusted In the beginning of the book.Timescale is very strict and doesn't Like any funny business In his congregation. This Is evident when Hester Is getting out of Jail and someone In the rood says â€Å"†¦ The Reverend Master Timescale, her godly pastor, takes It very grievously that such a scandal should have come upon his congregation. † (48). He does not support his flock being led Into temptation as he Is considered very righteous and for all everyone knows, he mind as well become the next Pope. He Is also well trusted amongst the people of New England.How much they trust him is best said by governor Bellingham, â€Å"the responsibility of this woman's soul lies greatly with you. It behooves you, therefore, to exhort her to repentance, and to confession, as a proof and consequence thereof. † (62). The people trust him with their souls, which, at that time period was worth more than anything in the world. In the middle of the book, timescale becomes guilty. No matter who you are, there is temptation. Timescale explains why he fell in to temptation and how he feels about Hester. â€Å"†¦ Old as I was, and misshapen as I was -, that the simple bliss which is scattered far and wide, for all mankind to gather up, might yet be This is how strongly timescale felt about Hester yet he continues to beat himself up for it. He explains this to Chlorinating indirectly when he asks, â€Å"you deal not, take it, in medicine for the soul! † (125). The reason he ‘needs medicine for the soul is becaus e of the guilt he feels for what the situation of Hester and pearl and being deceitful towards his people. At the end of the book, Timescale becomes free and reveals to the people who he really is.They say â€Å"His spirit rose, as it were, with a bound, and attained a nearer prospect of the sky, than throughout all the misery which had kept him groveling on the 85). Accepting the idea of running off with Hester and Pearl and not having to hide anymore relieving the stress he's had over the past years. Also, the people now truly know who he Is. â€Å"With a conclusive motion, he tore away his ministerial band from his breast. It was revealed! † (232). When the people see his â€Å"A† they realize whom Hester had sinned with and that the Reverend wasn't Just being modest about whom he Is.Throughout the book, Reverend Timescale changes. Everybody Changes, It's part of life. Sometimes, change Is bad, but, a lot of times change makes us better. For Timescale, even though It took his entire life, It finally set him free. Character analysis of The Scarlet Letter By timorous Character Analysis Essay: The Scarlet Letter throughout the book. Reverend Timescale changes in the beginning, middle and Rev Timescale is religiously strict and is well trusted in the beginning of the book.Timescale is very strict and doesn't like any funny business in his congregation. This is evident when Hester is getting out of Jail and someone in the crowd says â€Å"†¦ The Reverend Master Timescale, her godly pastor, takes it very does not support his flock being led into temptation as he is considered very righteous and for all everyone knows, he mind as well become the next Pope. He is feels about Hester. â€Å"†¦ Old as I was, and misshapen as I was that the simple bliss which is scattered far and wide, for all mankind to gather up, might yet be mine. (69). P for it. He explains this to Chlorinating indirectly when he asks, â€Å"you deal not, I the Accepting the idea of running off with Hester and Pearl and not people now truly know who he is. â€Å"With a conclusive motion, he tore away his they realize whom Hester had sinned with and that the Reverend wasn't Just being modest about whom he is. Throughout the book, Reverend Timescale changes. Everybody Changes, it's part of life. Sometimes, change is bad, but, a lot of times change makes us better. For Timescale, even though it took his entire life, it finally set him free.

Essay about Living or Dying with the American Dream

Everyone wants to be successful. We all dream of having a decent job, a house, a car or two, good social connections and the respect of our peers. We dream of opportunity and freedom. In Death of a Salesman by Arthur Miller, many characters are pursuing their own version of this dream, but they go about it in many different ways. Some see work and perseverance as necessities. Others think personal charm and popularity are essential in obtaining their dreams. We see the American Dream through the eyes of many different characters, giving us perspective of our own priorities and goals. Once we see the American dream from all of these angles we have to decide how we will interpret it, and how we will react. Willy Loman is the main person†¦show more content†¦In order to find that happiness we have to decide what makes us happy, and from the statements above we can say that it is opportunity, freedom and family. The sad part of this is a lot of us still manage to misinterpret what happiness means. Like several characters in Death of a Salesman, including Willy, many people think luxury and money is going to make them happy. British economist Richard Layard published a book entitled Happiness in which he discussed the results of several tests he ran. He discussed having a group of children that were asked how happy they were on a scale of one to ten. The childrens overall happiness level was about a six. Then each child got to select a â€Å"gift†, at random, from a bag. Again the children were asked how happy they were on a scale of one to ten. Surprisingly their happiness level had dropped. It was now a four. They were now materially â€Å"richer†, but they reported being less happy than before. This shows that wealth does not make us happy. So why do we, like Willy still think it will? (Professor Richard Layard on Happiness) (Carroll, 2012). 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