Organizational Governance And Leadership ( Mgmt20131 )

Organizational governance and leadership (MGMT20131) Name of the student: Muda Bhargav Kumar Student ID: s0283016 The following paper is mostly focused on the self-assessment of my organizational governance and leadership ability in keeping with development of integrated budget and planning system. The entire assessment includes the reflective practice of the leadership skills, research skills, analysis ability as well as problem solving skills in the practical context. The assessment paper greatly presents an opportunity to review the leadership topics. It reflects an experience in the leadership context at the time of working at DSS Consultancy. Moreover, the experience is properly analyzed for the identification of various challenges as well as the competency of the existing ideas. It also evaluates my emotional intelligence with the help of a useful questionnaire. Also, it also recommends the ways to strengthen the emotional intelligence. It also successfully discusses critique, use along with various aspects of emotional intelligence. Furthermore, it also compares the leadership experience with the literature. It discusses the probable influence of literature on my leadership style. Evaluation of the leadership experience: I have been assigned to lead the Southwest Region team for developing the integrated budget and planning system for the DSS consulting. At that time, I have experienced a very impressive experience regarding leading a diverseShow MoreRelatedLeadership Skills And Organization Of Walt Disney969 Words   |  4 Pages WALT DISNEY LEADERSHIP AND STRATEGY SUBJECT NAME : MGMT20131 Organizational and Governance Leadership GROUP MEMBERS : SHAIK AZHARUDDIN(s0273889) GAYAM SESHI REDDY(s0280903) SAI KIRAN PALLIKONDA(s0278967) SIVAPRAVEEN SIVASANKAR(s0277212) LECTURER NAME :

The Liberal Arts And Education - 1090 Words

A higher education prepares a student with knowledge to succeed professionally. The liberal arts focus is different as it prepares the student for a development of the mind, and perceptional differences within us as well as among each other. Some universities prepare the student with knowledge; however, Concordia University addition of the liberal arts program also prepares the individual with strengths of understanding the Bible, reflection, communication, and an ethical nature. The importance of the liberal arts in a university education is that it develops a student’s discipline of mind. These are transferrable skills regardless of a specific profession. Additionally, it delivers an understanding of the importance of reflection, moderation, and insight. This prepares individuals with problem solving skills and communication skills. These are important in dealing with everyday life experiences, especially with dealing with each other. John Newman explained, â€Å"This process of training, by which the intellect, instead of being formed or sacrificed to some particular or accidental purpose, some specific trade or profession, or study or science, is disciplined for its own sake, for the perception of its own proper object, and for its own highest culture, is called Liberal Education (Newman I.vii.1). This course covered a number of varied essays. Niccolo Machiavelli had a different perspective of Dr. Martin Luther King. Machiavelli’s view was that an effective leaderShow MoreRelatedA Liberal Arts Education1103 Words   |  5 Pagesmeans to think correctly in to find knowledge that is relevant and reliable. In terms of a liberal arts education critical thinking is crucial because a liberal arts education teaches students skills that are needed in the rapidly changing world that usually requires a lifetime of self-learning and understanding. Critical thinking is something that people usually must learn on their own; however, as a liberal arts school it is taught, so we have a better understanding of thinking critically. GreenRead MoreEducation And Liberal Arts Education1253 Words   |  6 PagesA study in general education (liberal arts) affects different aspects of my development both physically and mentally. A liberal arts education has shaped the form I conceive and return over individual circumstances. After attending class and reading all the benefits of a liberal arts education it has shaped the direction I held regarding a Liberal Arts education. A liberal arts education has shifted the way I study and the process I go about completing my school work. Furthermore, from the mannerRead MoreA Liberal Arts Education1448 Words   |  6 PagesA Liberal Arts Education A liberal arts education provides students with a broad spectrum of information enabling them to expand knowledge and to advance society in a positive direction. This universal education provides a strong foundation of knowledge in many subjects. The students can observe the strengths and capabilities, as well as the limitations of each field of study. This allows the students to find connections between diverse fields of study, to explore them, and to discover newRead MoreThe Liberal Arts And Education1501 Words   |  7 PagesThe liberal arts are a vital subject for the curriculum of every school worldwide. However, numerous education reforms set in motion by American government have begun to take a heavy toll on the existence of art programs in schools. Subjects such as theatre, music, dance, visual arts, and many more are being sacrificed economically in lieu of basic subjects that are listed as more important by the state. As a result of these funding cuts to arts programs, students across the nation are beginningRead MoreThe Importance Of A Liberal Arts Education972 Words   |  4 Pagesto a liberal arts school. There were many reasons why this was important to me, from having heard about it from my counselors to finding it important to have a broad education. I chose Hope College as the school I wanted to go to because it brought together the importance of God and Christianity and it also is a liberal arts sch ool. When arriving at the school, I began to find out more about how important a liberal arts education is to increase your knowledge. The first part of a liberal arts educationRead MoreQuestions On Liberal Arts Education982 Words   |  4 Pagesto take part in a college or university education usually decides what degree he/she wants to pursue before high school graduation; in some cases a liberal-arts degree is chosen. Misconceptions and critical opinions lead many to not take an interest in a liberal-arts education. In the article, â€Å"7 Major Misperceptions About the Liberal Arts†, Sanford J Ungar states that, We cannot assign different socioeconomic groups to different levels or types of education† (pp.2). I agree, but I also believe thatRead MoreThe Benefits of a Liberal Arts Education797 Words   |  3 PagesThe strength of a liberal arts education is the strong, varied foundation it provides over a wide spectrum of subjects. A liberal arts education is aimed at teaching you how to think. It helps you to develop strength of mind, and an ordered intellect. This broad-based education allows st udents to create new theories, discoveries, and connections between fields. With such expansive roots, great innovators can build and expand from what others have learned, instead of wasting effort on rediscoveryRead MoreImportance Of Liberal Arts Education1346 Words   |  6 Pages Before beginning my college journey, I had considered what I expected out of a liberal arts education. My number one reason for attending Central was for their education program. My goal for the future, however shallowly thought out it may have been, was to be a good teacher, and make a difference in children’s lives. Because of Central’s Teacher Academy program, their high standards, and excellent reputation in the field, I knew this was the place that would help me attain those goals. HoweverRead MoreHigher Education At The Liberal Arts1639 Words   |  7 PagesAll types of education, whether technical or liberal, possess their own inherent merit. The distinction between the two lie s in the spectrum of a particular study’s application. A higher education in any study should be encouraged because more knowledgeable individuals benefit both society and themselves through the continuation of their education. The value of one type of education does not negate the value of another. In today’s society technical studies, that is studies with a direct applicationRead MoreThe Liberal Arts Education Is Better Than A Education1409 Words   |  6 Pagesupon whether a liberal arts education is better than a vocational education; a topic that did not cross my mind in high school. A liberal arts curriculum includes the studies intended to primarily provide general knowledge such as language, philosophy, literature, and abstract science and to develop general intellectual capacities, such as reason and judgment, as opposed to professional or vocational skills (merriam-webster.com). As students wanting to achieve a higher education, we have to think

According to research done by Warr Free Essays

A lot of research has been conducted and hypothesis formulated to determine whether delinquent peer associations precede delinquency or vice versa. Another concern is how age influences delinquency and the interactivity or linkage among age, peer association, and delinquency. Consequently, the aim of this paper is to bring to fore, the various researches, theories and hypothesis that invariably throw more light on this issue. We will write a custom essay sample on According to research done by Warr or any similar topic only for you Order Now According to research done by Warr (1993), delinquency escalates rapidly as individuals enter their teen years and then declines almost as rapidly as they enter their late teens and early twenties. A possible explanation for this in my opinion is that youngsters in their early teens tend to be more adventurous and experimental. They are also easily influenced to try out new habits-good or bad- since often times, they are not experienced enough to know or care about the consequences of their actions. However, as they grow older and of course learn by experience, they inadvertently develop a more matured and balanced approach to the everyday choices they make. On another note, the fact that a peer group that you belong to engages in unlawful activities helps to validate its relevance and the feeling that it probably is the cool thing to do. Also, because humans are creatures of habit, once they start a habit, say alcoholism, it doesn’t take long before they become addicted. From another perspective, a criminal activity, say illegal drug use, can form part of general criteria for joining some particular peer groups. This can in no small way influence youths to indulge in these activities just to win the group’s approval or endorsement. A bone of contention among researchers is which comes first between delinquency and delinquent peer association? Research by Gottfredson and Hirschi (1987), support the notion that delinquency   actually comes before delinquent peer association. Similar researches performed by Thornberry (1994), Elliot and Menard (1996) however, offer opposing views. It is important to examine the role that age actually plays in delinquent acts. Hypothesis by Elliot and Menard (1996), show that both delinquency and delinquent peer association increase with age. A more insightful theory is the interactional theory by Thornberry (1987) that suggests that the influence of delinquent peer associations should increase during mid-adolescence and then decline gradually based on the reasoning that the hold that peer groups have on an individual is more pronounced during early stages of adolescence and less so as they grow older and commit to traditional activities like school, family, church, work etc. Still on the effects that age and delinquent peer association have on delinquency, the constant supervisory roles that teachers/guardians play in schools can douse the negative influences that delinquent peer associations can have on a young individual. However, as they advance in age and schooling, and move on to institutions of higher learning, the teachers or guardians tend to treat individuals as adults capable of making their own decisions. In other words, the supervisory roles that teachers play in the life of students reduce drastically as they advance in age and schooling. This also represents the theories expressed by Jang (1999:675). The interactional theory developed by Thornberry (1987) has been put to test but not without some loopholes. For instance, though the theory suggests that delinquent peer associations vary with age, it doesn’t specifically address the measure or category of offending. Also, a general inference tends to be made based on just one category of offending (e.g. drug offending). How to cite According to research done by Warr, Essays

The Shining free essay sample

Analysis of the Shining In the Shining, Stephen King’s idea was to show the reader that they don’t have to go looking in dark alleys for terrible monsters or demonic creatures, because in every human there is a chance for monsters to develop in ones mind. He also points out that a weak mind plus psychological problems, can allow exterior pressures to force you to think or do certain actions. In this novel the Torrance family settles in an isolated Colorado hotel, the Overlook. Jack Torrance, the father, gets a position as the winter caretaker. Jack, His wife and young son, Danny, are the only ones residing at the Overlook As the story unfolds you learn that Jack is a recovering alcoholic who has injured his son because of his own temper. His son, Danny has a psychic ability to read peoples thoughts and connect with spirits. The Overlook, the Hotel has a dark past and is very much alive with people that have died there long ago. We will write a custom essay sample on The Shining or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page As you read you realize the hotel will stop at almost nothing to add more spirits to its list. Stephen King reveals his ideas on mental illness and the influence that external pressures have on people. After Jack Torrance had given up drinking he was constantly fighting the urge to get a drink. . His dependency on alcohol caused Jack to almost become separated from his wife, led him to break his son’s arm, and his job loss as a teacher. He knew his father was an alcoholic and abused young Jack Torrance when he was a boy. Some days were good and others were not. Jack could no longer write his play; and would spend the day thinking about how he mistreated his family and how he wanted a drink. The hotel was now able to use his mental illness against him and influence his behavior. Jack would have drinks in the bar of the Colorado Lounge even though the liquor cabinets were abandoned of all bottles of any kind. He would drink and dance all night in the ballroom with the departed â€Å"guest†. This is where the previous care taker, one from the afterlife informed Jack that the hotel wanted him to be the manager forever. Jack only had to do eliminate his son and wife. Jack tried to pursue his new position, underlining Stephen kings message about the influence of external pressures on ones inner self. Because of Jacks mental illness the Overlook was able to influence his decisions.

Exosomes in Breast Cancer Essay Example

Exosomes in Breast Cancer Essay History of exosomes find The bringing of lading between intracellular compartments within cells by agencies of cysts has been surveies for many old ages. However, the acknowledgment that extracellular release of assorted types of cysts has complex biological results in multiple systems, including pathological conditions such as malignant neoplastic disease, has merely become apparent in recent old ages. Amongst several types of secreted cysts, exosomes were first described in 1981 as microvesicles incorporating 5-nucleotidase activity that were secreted from neoplastic cell lines ( Trams, et al. , 1981 ) . A few old ages subsequently, the secernment of cysts of endocytic beginning by civilized reticulocytes was reported. At the clip, some writers believed late endosomes were transitional comdepartments and their content was non thought to be recycled back to the plasma membrane, but destined for debasement in lysosomes. Consequently, these consequences were controversial, and were considered to be basically membranes shed by deceasing cells in civilization. In 1989, nevertheless, surveies observed the merger between late endosomes and the plasma membrane in cytotoxic T lymphocytes ( Peters et al. , 1989 ) , which proved that late endosomes were non merely transitional sections. The maps of exosomes were non widely studied until 1996, when surveies by Raposo and co-workers described exosomes bearing functional MHC category II molecules secreted by B lymph cells, triping renewed involvement in the survey of these cysts ( Raposo, et al. , 1996 ) . At present, exosomes have been demonstrated to show in a figure of organic structure fluids, such as piss ( Pisitkun et al. , 2004 ) , breast milk ( Admyre et al. , 2007 ) , blood plasma ( Caby et al. , 2005 ) , bronchoalveolar lavage fluid ( Admyre et al. , 2003 ) , amnionic fluid ( Keller et al, 2007 ) and malignant gushs ( Andre et al. , 2002 ) , bespeaking their importance in vivo.This study will concentrate on exosomes, which should non be confused with other secreted membrane cysts such as microvesicles, thatmicrovesicles, that have distinguishable structural and biochemical belongingss. Biology and composing of Exosomes We will write a custom essay sample on Exosomes in Breast Cancer specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Exosomes in Breast Cancer specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Exosomes in Breast Cancer specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Exosomes are characterised as membrane cysts with a size scope of 50-100nm. They are from endosomal beginning and are secreted by most cell types, such as hematopoietic, lymphocytes, dendritic cells, epithelial ( Van Niel et al. , 2001 ) , reticulocytes ( Johnstone et al. , 1987 ) and many tumor cells.Exosomes are limited by a lipid bilayer and can be formed through inward budding of endosomal membranes, giving rise to intracellular multivesicular organic structures ( MVB ) that subsequently fuse with the plasma membrane, let go ofing the exosomes to the extracellular environment. They can besides be formed by direct outward budding from the plasma membrane.The transportation of constituents between different compartments in a cell involves bearer cysts that bud from one compartment and so merger with another compartment after going in the cytol. These classical lading cysts display their cytoplasmatic side of the compartment they form from on their outer surface and stay intracellul ar. In contrast membrane cysts that are secreted into the extracellular environment display the extracellular side of the membrane they form from at their outer surface, so in consequence they could be considered as a illumination version of a cell.The molecular composing of exosomes depends on the types of cells they derived from. 1 is a conventional representation of a canonical exosomes. The proteins listed are found in at least 30 % of different exosomes, and proteins besides marked with an star are present in at least 50 % of exosomes.The cytosolic Rab protein that promote exosomes docking and membrane merger are present on exosomes. Annexin I, II, V and VI, may play a function in modulating membrane cytoskeleton kineticss and membrane merger events. Some adhesion molecules such as intercellular adhesion molecule-1, CD146, CD9, MFG-E8, CD11a, are besides present on exosomes. Proteins that are involved in programmed cell death are present on exosomes such as Alix and galectin 3. Heat daze proteins Hsp70 and Hsp90 are besides present, they are up-regulated under emphasis state of affairss and aid with protein folding and protect cells from emphasis. Exosomes besides contain tetraspanins including CD9, CD63, CD81 and CD82. Some proteins are cell-type specific ; MHC category I molecules are present in exosomes from most cell types, while CD86 and MHC category II molecules are merely present in exosomes that are derived from antigen-presenting cells ( APCs ) . Similar to proteins, lipid composing on exosomes besides varies. The typical lipid composing of exosomes derived from mast cells includes lysophosphatidylcholine, sphingomyelin, phosphatidylcholine, phosphatidylserine and cholesterin, etc ( Schorey et al. , 2007 ) . Isolation of exosomes Exosomes can be isolated based on their size, denseness and biochemical belongingss. The most widely used method of sublimating exosomes from cell civilization supernatant uses a series of centrifugations to take dead cells and cell dusts ( normally 1000 x g, so 10,000 x g ) , followed by a concluding high velocity ultracentrifugation ( 100,000 x g ) to pellet the exosomes ( Thery et al. , 2002 ) . A filtration procedure ( 0.2 millimeter ) can besides take cells and dust. This procedure does non know apart between exosomes and other little cysts though, as a effect, exosomes must be identified utilizing other extra standards. Furthermore, exosomes have a specific denseness ( ranges from 1.13 gml-1 to 1.19 gml-1 ) and can be purified by floatation into a sucrose denseness gradient or by sucrosedeuterium oxide shock absorbers ( Thery et al. , 2006 ) .Another purification method is based on the size and utilizes chromatography ( Taylor et al. , 2006 ) . In add-on, exosomes can be isolat ed based on their membrane belongingss. Beads coated with an antibody against a protein known to be expressed on the exosome membrane can be added to the supernatant after cell depletion, for illustration anti-MHC category II magnetic Dynabeads were used in Clayton and co-workers survey ( Clayton et al. , 2001 ) . One disadvantage of this isolation method is that all the exosomes will merely be selected if they all contain the protein used for the isolation, otherwise, merely a proportion of the exosomes will be selected. A Good Fabrication Practice ( GMP ) approved method has been established for the isolation of exosomes used for clinical applications, which is based on extremist filtration and diafiltration followed by centrifugation on sucrose shock absorbers, ensuing in a extremely purified and unfertile exosome pellet ( Lamparski et al. , 2002 ) . This method is best suited for when large-scale exosomes isolations are needed and requires specialized equipment. There is a turn ing demand for a fast, efficient and dependable method that yields extremely purified exosomes suited for both research and clinical intents. Exosomes can do immune-activating responses in vitro Exosomes secreted from antigen-presenting cells contain a scope of immunostimulatory molecules that activate T cells, which suggest that they may hold an of import function in extension of immune responses.Exosomes derived from bacterially infected macrophages carry bacterial coat constituents and utilize these to excite a proinflammatory response in naif macrophages ( ONeil et al. , 2008 ) . It was demonstrated by Giri et Al that exosomes isolated from M. bovis and M. TB infected macrophages besides lead to activation and ripening of dendritic cells that derived from mouse bone marrow. Furthermore, intranasal disposal of mice with exosomes isolated from M. bovis BCG infected macrophages stimulated the coevals of memory CD4+ and CD8+ T cells. This indicated that the exosomes from infected macrophages might be a possible vaccinum campaigner for TB ( Giri et al. , 2008 ) .Human dendritic cell-derived exosomes ( Dex ) express NKG2D ligands ( activatory signals for Natural Killer cells ) such as MHC category I polypeptide-related sequence A ( MICA ) and MICB on their surface that bind to NKG2D that are present on NK cells and lead to NK cell activation ( Viaud et al. , 2009 ) . IL-2 and trans-presentation of IL-15 and IL-15 receptor a concatenation ( IL-15Ra ) is required for NK cell endurance, homeostasis and proliferation. The ability of Dex to advance NK cell proliferation was due to the coincident presence of IL-15Ra on these exosomes, which could adhere to exogenic IL-15 and let IFNg secernment by NK cells therefore stimulate NK cell proliferation.Dex express high degrees of functional MHC class-I and class-II peptide composites together with CD86 molecules and it has been suggested that Dex may replace for DCs to arouse MHC-class-I and class-II restricted T-cell responses and tumour rejection.Tumour-derived exosomes can besides hold immune-activating belongingss. This chiefly happens when the tumor cells are under stress conditions. The stress-inducible HSP 7 0 household is considered to work as an endogenous danger signal that can increase the immunogenicity of tumors and bring on cytotoxic T lymphocytes ( CTL ) responses. They are a cardinal portion of the cell s mechanism for protein folding, and they help to protect cells from emphasis.It was demonstrated that stimulation of 4T1 chest glandular cancer cells and K562 erythroleukemic cells with IFN-g leads to cellular emphasis response, which so triggers enhanced look of entire Hsp72 ( HSP70 household ; 72 kDa ) look without increasing cell programmed cell death significantly. It was revealed that Hsp72 is released within exosomes and has the ability to up-regulate CD83 look and excite IL-12 ( a T cell exciting factor ) release by naif dendritic cells ( Bausero et al. , 2005 ) .Under emphasis conditions, NKG2D ligands are up-regulated on tumour exosomes. Hsp70 besides activates mouse NK cells that recognize stress-inducible NKG2D ligands on tumor cells. In the SCID mice with Hsp70-over expressing tumors, NK cells were activated so that they killed ex vivo tumor cells that expressed NKG2D ligands ( Elsner et al. , 2007 ) Exosomes can besides hold immunosuppressive belongingss in vitro Immune equivocation by tumor cells is a good established mechanism wherein tumours avoid sensing and riddance by the host immune system. Tumour-derived membrane cysts have been reported to hold immunosuppressive maps for over 20 old ages ( Poutsiaka et al. , 1985 ) .Fas ligand ( besides known as CD95 ligand ) is a type II transmembrane protein of the Tumour Necrosis factor ( TNF ) household. When FAS ligand binds with its receptors, programmed cell death will be induced. Exosomes derived from tumor cell lines bear Fas ligand that can bring on T cell programmed cell death taking to suppression of T-cell responses in vitro. Addition of anti-FasL antibody blocked exosome-induced programmed cell death ( Abusamra et al. , 2005 ) .In malignant neoplastic disease patients, the loss of NKG2D, an energizing receptor for NK cells, CD8+ and NKT cells, is a critical mechanism of malignant neoplastic disease immune equivocation. NKG2D down-modulation is due to direct exosomal bringing of membrane -bound transmembrane growing factor b1 ( TGFb1 ) to CD8+ T cell or NK cell subsets ( Clayton et al. , 2008 ) . Down-regulation of NKG2D is partially due to the presence of the expressed NKG2D ligand MICA. Clayton and co-workers demonstrated that other possible NKG2D ligand such as MICB may be present on the surface of tumour-derived exosomes, and may lend to the down-regulation of NKG2D. On the other manus, some experiments added combinations of other NKG2D-ligand specific Abs did non accomplish a convincingly enhanced inhibitory consequence, but this may be consequence of the hapless barricading features of the Abs. In comparing, adding a TGFb1-blocking Ab about wholly abrogated the decrease in surface NKG2D. These informations suggest that down-regulation of NKG2D is chiefly due to the presence of TGFb1 and partially due to the presence of NKG2D ligands, but how exactly TGFb1 and NKG2D ligands cooperate requires elucidation.Interleukin 2 ( IL-2 ) is an of import cytokine which non merely supports enlargement and distinction of cytotoxic T cells and Natural Killer ( NK ) cells, but besides supports regulative T cells ( Treg cells ) and their suppressive maps ( Clayton et al. , 2007 ) . Tumour exosomes inhibit IL-2 induced T cell proliferation by advancing the map of Treg cells.It has besides been reported that tumour exosomes-mediated initiation of IL-6 plays a function in barricading bone marrow DC distinction. The degrees of IL-6 and phosphorylated Stat3 were elevated 12 hours after the tumor exosomes stimulation of murine myeloid precursors, and tumour exosomes were less efficient in suppressing distinction of bone marrow cells isolated from IL-6 smasher mice. It was suggested that bone marrow DC precursors capture tumour exosomes and later bring on the production of IL-6 and other cytokines, taking to the activation of Stat3. As a consequence, distinction of bone marrow precursors into immature DC is blocked ( Yu et al. , 2007 )Immune cell-derived cysts c an besides hold immunosppressive belongingss. Activated T cells secrete exosomes bearing FasL, which induces programmed cell death of bystander T cells, thereby take parting in activation-induced cell decease ( AICD ) . Ectosomes derived from neutrophils and erythrocytes inhibit the secernment of IL-8 and TNF by macrophages and the ripening of DCs ( Thery et al. , 2009 ) .Vesicles purified from some organic structure fluids can besides hold immunosuppressive activities. Exosomes from human chest milk in vitro inhibit T cell activation and increase the figure of Treg cells ( Admyre et al. , 2007 ) . It was suggested that exosomes present in chest milk may hold a function in the immune tolerance of the baby and may besides protect the baby from allergic reaction development.MIC molecules are reported to be constitutively transcribed in human placenta throughout normal gestation and soluble MIC molecules are released from in vitro cultured placenta explants.Elevated degrees of soluble MIC molecules are present in gestation sera and are able to down-regulate the NKG2D receptor and impair the cytotoxic map of peripheral blood mononucleate cells from healthy givers. Take together, these consequences suggest a fresh mechanism for immune equivocation of the fetal homograft through foetal MIC and maternal NKG2D interactions ( Mincheva-Nilsson et al. , 2006 ) . A more recent survey by the same group showed that the 2nd household of human NKG2D ligands, the UL-16 binding proteins ( ULBP ) , is besides expressed by placenta. Isolated placenta exosomes carried ULBP1-5 and MIC on their surface and induced down-regulation of the NKG2D receptor on NK, CD8+ , and gd T cells, taking to decrease of their in vitro cytotoxicity without impacting the perforin-mediated lytic tract ( Hedlund et al. , 2009 ) Antigen presentation by Exosomes Exosomes can show antigens straight or indirectly. Secreted membrane cysts carry both antigenic stuff and peptide-MHC composites. Exosomes can besides reassign antigens from tumour cells to DCs and maps in antigen cross-presentation. Exosomes purified from cultured tumor cell lines contain tumour antigens and can bring on the activation of antigen-specific T cells in vitro in the presence of recipient dendritic cells, which have otherwise non encountered the antigen.Secreted cysts display preformed peptide-MHC composites on their surface that can sometimes be straight presented to T cells. Exosomes and microvesicles derived from most cell types bear MHC category I molecules that could potentially bring on CD8+ T cell activation ( Thery et al, 2009 ) . It was reported that Dendritic cells ( DC ) derived exosomes could straight bring on the activation of CD8+ T cell in an antigen-specific mode ( Admyre et al, 2006 )Antigen showing cell ( APC ) derived exosomes express big sums of MHC c ategory II molecules. These exosomes can straight trip blood relation T cell ringers or pre-activated CD4+ T cells, but they need to reassign antigen and MHC molecules to dendritic cells, which will so trip naif CD4+ T cells ( Thery et al, 2009 ) . Shuttle for RNA A more recent progress in the field of exosome survey has been the find that these cysts can besides incorporate, and deliver, species of RNA molecules that can be active in cells that take up the exosomes. A survey by Skog et Al. showed that Glioblastoma-derived exosomes are enriched in messenger RNA and miRNA. They showed that messenger RNA could be delivered into receiver normal cells and bring forth a functional protein. It was besides shown that spongioblastoma microvesicles seem to excite proliferation of a glioma cell line ( Skog et al, 2008 ) . Valadi et Al. showed similar consequence, with a presentation that the messenger RNA nowadays in exosomes was active and functional ( Valadi et al. , 2007 ) . Their designation of RNA being present in exosomes supports the hypothesis that exosomes may be a bringing vehicle by which one cell communicates with another, really presenting RNA and, in bend, modulating recipient-cell protein production. Transportation of infective agent HIV atoms utilize multivesicular compartments that are enriched in MHC II and CD63 as the major site for accretion in human macrophages. And the virus released has proteins normally found on exosomes. These findings formed the background for the Trojan virus hypothesis , which suggested that viruses such as HIV could commandeer and conceal in exosomes secreted from an infected cell, and because the retroviruses are released in the signifier of exosomes, they could so get away the host defence. It has been demonstrated that the cellular prion protein ( PrPc ) and the transformed infective PrPscrapie ( PrPsc ) are found in exosomes secreted into the civilization medium and exosomes that express PrPsc were infective, bespeaking the function of exosomes in the spread of prions ( Fevrier et al. , 2005 ) The map of membrane secreted vesicles/exosomes in vivo The function of exosomes secreted in vivo is still in argument and demands to be to the full determined. Exosomes isolated from gestations later presenting at term expressed significantly higher degrees of biologically active constituents, including Fas ligand and HLA-DR, than those from gestations presenting preterm. A survey by Taylor et al indicated that exosomes with T-cell inhibiting activity are increased in pregnant adult females who deliver at full term comparison to adult females who deliver pre-term ( Taylor et al. , 2006 ) . Use of exosomes as possible immunotherapy vaccinum. Tumour cell-derived exosomes incorporating tumor antigens plus MHC category I molecules can reassign tumour antigens to DCs to bring on a CD8+ T cell dependent antitumour immune response. Exosomes released from DCs pulsed with tumor antigens were besides shown to arouse strong anti-tumour responses. One survey compared exosomes derived from tumor cells and exosomes derived dendritic cells in facet of the stimulatory efficiency of the antitumor immune responses induced by these two normally used exosome vaccinum. Dendritic Cell-Derived Exosomes Stimulate Stronger CD8+ CTL responses and antitumor unsusceptibility than tumour cell-derived exosomes ( Hao et al. , 2006 ) .Inoculation of CBA/J mice with exosomes secreted by SRDCs pulsed in vitro with Toxoplasma gondii-derived antigens ( TAg ) before gestation induced a protective response in the progeny. In fact, inoculation resulted in the presence of significantly fewer cysts in offspring encephalons ( Beauvillain et al. , 2009 ) . Clinical tests Two stage I clinical tests have been carried out on patients with advanced phase melanomas or non-small cell lung carcinomas showing melanoma-associated antigen ( MAGE ) . These tests required the constitution of good fabrication processs ( GMPs ) to obtain clinical-grade exosomes from patients DC loaded with tumour antigen derived peptides. These surveies proved that it is executable and safe to give exosomes to human topics and the exosomes are efficient in bring oning antigen-specific T-cell responses. The lone side effects were mild localised reactions at the site of injection and mild febrility in a few patients. The clinical results were encouraging, demoing transeunt stabilisation of the disease in half of the patients in the melanoma test and a 3rd of the patients in the lung carcinoma test.Another study that studied the usage of ascites-derived exosomes ( Aex ) in combination with the granulocyte-macrophages colony-stimulating factor ( GM-CSF ) in the immunotherapy of color ectal malignant neoplastic disease was besides published. 40 patients with advanced colorectal malignant neoplastic disease were involved in this survey and they were indiscriminately allocated to interventions with Aex entirely or Aex with GM-CSF. Both interventions were safe and the Aex plus GM-CSF can bring on tumour-specific antitumour cytotoxic T lymph cell ( CTL ) response ( Dai et al. , 2007 ) .Based on these consequences, a stage II clinical test is about to be initiated in France in patients with non-small cell lung malignant neoplastic disease that as been stabilized by chemotherapy. This survey will unite the disposal of exosomes from IFNg-treated DCs ( which express NKG2D ligands and IL-15Ra ) , and will use attacks that inhibit T Reg cells ( Mignot et al. , 2006 ) . Breast Cancer Breast malignant neoplastic disease is the 2nd major cause of malignant neoplastic disease decease in American adult females, with an estimated 40,170 lives lost in adult females in the United States in 2009 ( Jemal et al. , 2009 ) . Although ovarian malignant neoplastic disease histories for fewer deceases than chest malignant neoplastic disease, ovarian malignant neoplastic disease still represents 4 % of all female malignant neoplastic diseases. For some of the instances of both types of malignant neoplastic disease, there is besides a clear familial nexus.In 1994, two chest malignant neoplastic disease susceptibleness cistrons were identified: BRCA1 on chromosome 17 and BRCA2 on chromosome 13. When persons have a mutated BRCA1 or BRCA2 cistron, they are at an increased hazard of developing chest or ovarian malignant neoplastic disease at some phases of their lives. Until late, it was non clear what the map of these cistrons was, until surveies on a related protein in barm reveale d their normal function: they participate in mending radiation-induced interruptions in double-stranded DNA. It is thought that mutants in BRCA1 or BRCA2 might disenable this mechanism, taking to more mistakes in DNA reproduction and finally to cancerous growing.This will be the first survey that compares normal mammary epithelial cells-derived exosomes and breast cancer-derived exosomes. Research Proposal The primary purpose of my undertaking is to insulate and qualify exosomes and to compare the immune-modulating belongingss of exosomes secreted from normal chest epithelial cell line ( B42 ) and a tumour line derived from it ( B42 clone 16 ) ( Weaver et al. , 2009 ) . I will measure if the normal and malignant neoplastic disease derived exosomes influence lymphocyte maps and tumour growing. Both cell lines are cultured in a serum-free growing medium incorporating Clonetics Mammary Epithelial Basal Media ( MEBM ) and MEGM SingleQuot addendums ( Cambrex ) . This information will so be used in a comparative analysis of patient derived stuff.Flow cytometry was used at the start to place the belongingss of the atoms present in the cell civilization supernatant. PBS on its ain was compared to man-made beads of size 48 nanometer, 100 nanometer and 410 nanometer. And consequences show that the size of the little atoms present in the cell line supernatant was less than 100 nm as seen in 2F, 2 G and 2H. Analysis of the MEBM medium utilizing flow cytometry showed that there were little atoms with size less than about 300nm as seen in 2E. A fact that must be considered in all exosome surveies is that civilization media addendums, such as FBS, can besides incorporate exosomes. Therefore media supplememts should either be avoided if executable, or pre-spun at 100,000 ten g to take exosomes. To turn out that the little atoms we detected were secreted from the cells and non from the civilization medium, we so stained our cells with Carboxyfluorescein succinimidyl ester ( CFSE ) , which is a fluorescent cell staining dye. B42 cells were incubated with CFSE in PBS ( concentration of CFSE is 10 Â µM ) at room temperature in dark for 10 proceedingss. The CFSE was so removed by rinsing the cells and 10ml of growing medium was added in the flask, which was so put in the brooder. 1ml of supernatant was taken out after 24, 48 and 72 hours, and was so analysed by flow cytometry. P A ll atoms detected in supernatants from cells are fluorescent as seen in 3 A, 3B, 3C, 3D and 3E, which indicates that they are secreted from the cells.Immunoblotting has besides been utilised to characterize the stray cysts. 50ml of 5-day normal cell supernatant and 35ml of 5-day tumor cell supernatant was used. Exosomes were isolated utilizing centrifugation at 1500rpm ( 100 x g ) followed by ultracentrifugation at 24,000 revolutions per minute ( 100,000 x g ) utilizing a SW28 rotor for three hours. Supernatant was poured off and the pellets were resuspended in PBS. The protein concentration was determined to be: normal cell-derived exosome pellet 344 mg/ml, tumor cell derived pellet 535 mg/ml.Both samples were resuspended in SDS cut downing sample buffer ( 2 % SDS, 20 % Glycerol, 0.05 % bromophenol blue, 0.5 M Tris pH6.8 and Dithiothreitol as the cut downing agent ) and denatured by heating at 70 Â °C for 1 minute. Electrophoresis was carried out in SDS-PAGE running buffer for abo ut 1 hr at 150 VProtein samples were so transferred onto a nitrocellulose membrane ( in blotting buffer ( 25mM Tris, 192mM Glycine ) at 100 V for about 30 proceedingss ) . Ponceau S was used to look into the protein transportation. The nitrocellulose membrane was washed in H2O and so with PBS+ 0.1 % Tween 20. Barricading buffer ( PBS+0.1 % Tween and 5 % Skimmed milk pulverization ) was so added and the membrane was left on a shaker for about 15 proceedingss. Primary antibodies ( Alix, Tsg101. HC10 ) were diluted into PBS+ 0.1 % Tween ( 1/1000 dilution ) and incubated with the membrane and were left on a shaker in a cold room overnight.Membrane was washed 3 times with PBS+0.1 % Tween at 10 proceedingss intervals. Secondary antibody IgG-HRP was diluted in PBS+0.1 % Tween ( 1/1 0, 000 dilution ) and was incubated with the membrane for about 20 proceedingss. Membrane was so washed 3 times with PBS+0.1 % Tween at 10 proceedingss intervals. 1ml of PBS, 300 m cubic decimeter of Peroxide an d 300 m cubic decimeter of foil ( Super signal West Femto ) was assorted together and incubated with the membrane for about 1 minute. Excess fluid was so absorbed with tissue. Antibody binding was so visualised with Fujifilm Intelligent Dark Box LAS-3000.The consequences are shown in 6. Typical exosomes surface markers such as MHC Class I, ALIX and TSG101 can be visualised. As this is merely the preliminary consequence and the burden of normal and tumour exosomal protein was non equal, this experiment will be repeated in the hereafter. Future experiments: 1. It has already become evident that a confining factor in the experimental system we have developed is the sum of exosomes that can be harvested from civilization supernatants. Non-adherent lymphoid lines can be grown to high denseness, with good outputs of exosomes. In contrast, adherent cells, such as the chest lines being used in this survey, can non be grown to such high denseness in normal flasks, with a ensuing lower output of stuff. However, in communications with other exosome research workers, we are obtaining similar sums from these standard flasks.Therefore to better outputs we will look into the usage of fresh tissue civilization techniques. Two methods are executable. First, the usage of the Integra Celline system, which are particular flask incorporating a membrane edge inner compartment where cells are seeded, an external compa R tment where civilization medium is placed. This system is presently in usage by the Clayton group in Cardiff. Its chief disadvantage is the cost of each single flask is in the part of ?150. Whilst good pattern should let extended usage, accidental infection or the demand for a fresh batch of cells would necessitate another new flask. Therefore, the system will we prove will be the usage of microcarries, which are little dextran-based domains on which disciple cells grow. Adding these to standard flasks can therefore increase the surface country greatly.Cell growing and exosome production will be optimised utilizing Cytodex 1 bearer beads. A methodological analysis paper has been published for the usage of the Celline flask system in exosomes production, but non for microcarriers, therefore it is a possible paper as good.2. The flow cytometry informations shown above, whilst declarative mood of little cysts in the civilization medium, does non turn out that they are exosomes. We will utilize flow cytometric screening to farther characterise these cysts, with the end of identifying and screening microvesicles from exosom es. Such a technique could hold great value in the analysis of cyst biomarkers in patient samples.3. Exosomes will be obtained through standard high-velocity ultracentrifugation. The proteins present on these exosomes will be analysed in order to analyze the composing of the exosomes. Western smudge and flow cytometry will be used to analyze exosomes markers associated on the normal and tumour cells. two-dimensional gel electrophresis will be used to qualify any differences between normal and tumour cells, proteins can be so analysed by mass spectroscopy, which identifies the protein. Whether exosomes will impact the growing of blood lymph cells harvested from healthy givers will be studied. We will besides utilize tumour-derived exosomes to find if they affect the growing of Normal and tumour cells. Finally, we will analyze whether exosomes are present in the serum of chest malignant neoplastic disease patients and analyze its possible usage as a diagnostic tool.Experiments will be carried out to see whether tumour exosomes can intercede anchorage-independent growing of the chest malignant neoplastic disease cell line. We will besides analyze whether exosomes are present in the serum of chest malignant neoplastic disease patients. Mentions Abusamra, A, J. , Zhong, Z, H. , Zheng, X, F. , Li, M. , Ichim, T, E. ,Chin, J, L. A ; Min, W, P. ( 2005 ) . Tumor exosomes showing Fas ligand mediate CD8+ T-cell programmed cell death. Blood cells, Molecules, and Diseases. 35:169-173Admyre, C. , Grunewald, J. , Thyberg, J. , Gripenback, S. , Tornling, G. , Eklund, A. , Scheynius, A. A ; Gabrielsson, S. ( 2003 ) . Exosomes with major histocompatibility complex category II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J. 22: 578-583.Admyre, C. , Johansson, S, M. , Paulie, S. A ; Gabrielsson, S. ( 2006 ) . Direct Exosome stimulation of Peripheral Human T Cells Detected by Elispot. Eur. J. Immunol. 36:1772–1781Admyre, C. , Johansson, S, M. , Qazi, K, R. , Filen, J, J. , Lahesmaa, R. , Norman, M. , Neve, E, P, A. A ; Scheynius, A. ( 2007 ) . Exosomes with Immune Modulatory Features Are Present in Human Breast Milk. J. Immunol. 179: 1969-1978Andre, F. , Schartz, N.E.C. , Movassagh, M. , Flament, C. , P autier, P. , Morice, P. , Pomel, C. , Lhomme, C. , Escudier, B. , Le Chevalier, T. , Tursz, T. , Amigorena, S. , Raposo, G. , Angevn, E. A ; Zitvogel, L. ( 2002 ) . Malignant gushs andimmunogenic tumour-derived exosomes. The Lancet. 360: 295-305.Bausero, M, A. , Gastpar, R. , Multhoff, G. A ; Asea, A. ( 2005 ) . Alternate mechanism by which IFN-g enhances Tumor acknowledgment: Active Release of Heat Shock Protein 72. J. Immunol. 175:2900-2912Beauvillain, C. , Juste, M, O. , Dion, s. , Pierre, J. A ; dimier-Poisson, I. ( 2009 ) . Exosomes are an effectual vaccinum against inborn toxoplasmosis in mice. Vaccine. 27:1750-1757Caby, M. P. , Lankar, D. , Vincendeau-Scherrer, C. , Rapo

Free Essays on Arctic Hunt

As with many or all hunting initiatives in Canada the seal hunt is controlled and subsidized by the government. In an effort to control the seal population and prevent to ecosystem from being thrown off the government sees that they need to allow the hunt. To ensure that the hunt is performed to the correct size, the government subsidizes the hunt so things are made easier, and more plausable for "sealers" and commercial companies to access the frozen waters and beaches in proper numbers. Overpopulation of any particular animal can upset the balance of the ecosystem and even effect the economy. This is why the government supports the agenda of the annual hunt. If the seal population becomes to great, they will eat all the fish and kill the fishing industry. Furthermore with the fish gone, the seals then begin to starve and die off. This is an issue once more for the government because then they are required to reintroduce species of fish to the area, which is both expensive an d time consuming. Thus the economy suffers again. For the government to turn a blind eye to this would be perilous, which is why the involve themselves. Methods of the seal hunters is generally simple, effective, and traditional. They use various methods, most classic of all is clubbing. The hunter uses a club similar to a baseball bat to simply beat the baby seal to death. This does not always result in instant death. Another tool they use is a large pike with a hook on the end. Used for seperateing and stabbing the seals, it is more effective in landing a lethal blow than the clubbing method. Thirdly, and most simply and modern, is some of the sealers will just simply shoot the seal with a gun. However non-traditional, this is a very effective means of ensuring the pup is no longer alive when the next steps begin. After killing the seal, the hunter will use a hooking system to hook and drag his kill from the icey waters, or over to a safe locati... Free Essays on Arctic Hunt Free Essays on Arctic Hunt As with many or all hunting initiatives in Canada the seal hunt is controlled and subsidized by the government. In an effort to control the seal population and prevent to ecosystem from being thrown off the government sees that they need to allow the hunt. To ensure that the hunt is performed to the correct size, the government subsidizes the hunt so things are made easier, and more plausable for "sealers" and commercial companies to access the frozen waters and beaches in proper numbers. Overpopulation of any particular animal can upset the balance of the ecosystem and even effect the economy. This is why the government supports the agenda of the annual hunt. If the seal population becomes to great, they will eat all the fish and kill the fishing industry. Furthermore with the fish gone, the seals then begin to starve and die off. This is an issue once more for the government because then they are required to reintroduce species of fish to the area, which is both expensive an d time consuming. Thus the economy suffers again. For the government to turn a blind eye to this would be perilous, which is why the involve themselves. Methods of the seal hunters is generally simple, effective, and traditional. They use various methods, most classic of all is clubbing. The hunter uses a club similar to a baseball bat to simply beat the baby seal to death. This does not always result in instant death. Another tool they use is a large pike with a hook on the end. Used for seperateing and stabbing the seals, it is more effective in landing a lethal blow than the clubbing method. Thirdly, and most simply and modern, is some of the sealers will just simply shoot the seal with a gun. However non-traditional, this is a very effective means of ensuring the pup is no longer alive when the next steps begin. After killing the seal, the hunter will use a hooking system to hook and drag his kill from the icey waters, or over to a safe locati...

Consider one area of Tort law which you feel policy factors have had a Essay

Consider one area of Tort law which you feel policy factors have had a particular part to play in the development of the law.(Have chosen police immunity) - Essay Example There are four inherent elements to this negligence. These elements include the notion that there is a duty to exhibit a reasonable amount of care when dealing with another individual, the breach of that duty, the notion that the breach of that duty caused physical harm to another individual and finally, the breach did in fact cause harm from a legal standpoint. In order to examine the police immunity with regards to breach of duty within the realm of the tort of negligence, it is prudent that we examine the background of breach of duty and the charge of negligence resulting from it.1 The tort of negligence like all other legal causes in common law arose out of a necessity based on reason wherein many different actions were brought based on the fault of individuals with regards to inflicting harm on others as a direct result of carelessness. It dates back to the case of Heaven v Pender (1885). This was the first case wherein negligence was alleged wherein Pender who was a dock owner charged with the responsibility of putting up a staging outside of a ship owned by another party. He placed the staging up. An employee, who was subcontracted to paint the ship, mounted the staging and was hurt when one of the ropes supplied by the defendant broke and caused the plaintiff to sustain injuries. The plaintiff then brought a suit against Mr. Pender as Mr. Pender did supply the defective rope that eventually broke. Additionally, there was evidence that the rope had been scorched and there was prior knowledge that the rope was unfit for supporting the staging. The judge in this case ruled for the plaintiff and established a precedent with regards to negligence arising from a breach of duty.2 Yet another early case in establishing the tort of negligence is the case of Le Lievre v Gould [1893] which called to task the notion of professional negligence. Professional negligence according to common

Emergency Management (Radio and cellular communications) Assignment

Emergency Management (Radio and cellular communications) - Assignment Example This scenario has been observed every time there is a disaster; thus, this event deserves to be a part of disaster drills. Disaster drills are created for disaster mitigation and successful response, and it is just right to start with the assumption â€Å"cell phones don’t work.† Cell phones are wireless communications that have wide geographical connectivity and â€Å"multiple modes of communication† (i.e. internet, e-mail, texting, & making calls) (Smith, Darling, & Searles, 2011, p. 378). Normally, a rapid exchange of quality information is happening when disaster hits because there is a strong demand for an instant reconnection/messaging, tracking locations, and other disaster responses (Phillips, Neal, & Webb, 2011, p. 412). However, it is discouraging that cell phones are not working when it is needed the most; hence, this assumption is accurate. Disaster drills that are based on this assumption are effective because they have â€Å"forced people to improv ise by adopting technologies new to them and by using familiar technologies...† like femtocell, communication redundancy, satellite phones, etc., that will continue working during disasters (Shklovski, Burke, Kiesler, & Kraut, 2010, p. 1231). The expectation that cell phones must efficiently work during disasters is difficult to meet; thus, cell phone networks should set users’ expectation with their capabilities. They should give importance on load balancing and equal distribution of frequency, particularly during disasters. management: Common ground, contribution and future research opportunities for two emerging disciplines. In D. A. McEntire (Ed.), Disciplines, disasters, and emergency management: the convergence and divergence of concepts, issues and trends from the research literature (pp. 272- 283). Springfield, Illinois: Charles C Thomas Publishers. People

Design & defend an optimal performance appraisal system for a position Research Paper

Design & defend an optimal performance appraisal system for a position you aspire to hold (medical supervisor) - Research Paper Example The typical methodology geared to dealing with performance appraisal systems relies on using a generalized approach where one performance appraisal system is used for a number of different hierarchical positions in an organization (Cascio, 2013). However, it would only make sense to design a performance appraisal system that is attuned to the needs of a particular position being appraised. This paper attempts to design an optimal performance appraisal system for the position of a medical supervisor based on current research findings. Description of Position The performance appraisal system under design is for the position of a medical supervisor. Essentially the position requires a large amount of daily interaction with patients as well as members of staff and occasionally contact with members of regulatory agencies. Additionally, the medical supervisor represents a senior position at any medical institution and is responsible for overseeing the training and skill development of his subordinates. The medical supervisor needs to keep tabs on the budgeting of resources and scheduling of staff members to ensure uninterrupted medical service to patients. The multifaceted nature of the job of a medical supervisor means that the incumbent medical supervisor needs to be ready on all fronts to deliver in order to be relevant to the organization’s overall objectives. Proposed Optimal Appraisal Performance System The proposed appraisal performance system for the position of a medical supervisor is divided into sections based on the major responsibilities for the position. The responsibilities are segregated through broad overviews since the current paper is not intended to dissect all of the responsibilities in complete detail. The primary responsibility of a medical supervisor is to the patients under treatment. Patients can be seen as the customers for any medical system so delivering to the customers is of the utmost importance. The medical supervisor is suppor ted by his staff at various levels and positions in order to service the patients so dealing with staff is a secondary responsibility to ensure satisfactory service provision at least. Moreover, the medical supervisor is responsible to his immediate superiors and members of regulatory agencies such as the American Medical Association (AMA) who require consistent feedback for continuous performance assessment. Performance Appraisal for Patients The basic contention behind performance appraisals is to provide employees with feedback regarding their performance (Broady-Preston & Steel, 2002). In the case of medical institutions, the customers are patients under treatment. Performance appraisal needs to emanate from patients and their relatives who judge the quality of services being delivered by a medical supervisor. Essentially such a grass roots level performance appraisal system bases itself on the 360 degrees appraisal system proposed by Milliman (1994). The idea behind such an app raisal system is to ensure that all people interacting with an employee especially customers provide their effective feedback in relation to the employee’s attitude and behavior (Cascio, 2013). This provides the medical supervisor with a more goal oriented performance appraisal system that encourages a quantitative method to evaluate job

The Types Of Pasta

The Types Of Pasta Delicious, healthy, quick to cook and, above all, economical pasta really is the ultimate convenience food. Whether simply tossed with a sauce, fresh vegetables or salad ingredients, or combined as a dish and baked in the oven, pasta can be used as the base of countless fabulous meals. And because there are so many different types of pasta fresh or dried, long or short, stuffed or flat and so many ways of combining them, from the ultra-simple to the impressively sophisticated, there really is a pasta dish for every occasion. Of the many, many different types of pasta available, they can be divided into four main categories: long, short, flat and stuffed. In turn, these many be fresh or dried, with wholemeal varieties available in some shapes, and made of durum wheat flour and water, or with additional egg. They may also be coloured and flavoured with spinach (green), tomato (red), beetroot (pink), saffron (yellow), squid ink (black) and herbs. Fresh pasta is delicious, although not necessarily better than dried pasta and many Italians will choose dried pasta over fresh for specific dishes. As a rule of thumb, buy the best pasta you can afford, as it will make all the difference to the final flavour and texture of the dish. LONG PASTA Most types of long pasta are sold dried, and some are also available fresh. They vary in length and may be sold in straight lengths, pressed into waves or coiled into nests. They are usually made from plain durum wheat. Those made with delicate egg pasta are usually sold coiled into nests. Most long pastas suit smooth, creamy and clinging sauces. Common varieties include: à ¢-  Bucatini Resembling thick spaghetti, each strand is hollow. There is a thicker version known as bucatoni. à ¢-  Capelli dangelo Also called angel hair pasta, this very long, thin pasta is like delicate vermicelli and is sold in nests. It is usually served with sauce, or in soup. Figure 2.2 Capelli dangelo à ¢-  Fettuccine Long, flat ribbons sold in nests. It may be plain, with egg or with spinach. It can be used interchangeably with tagliatelle. Figure 2.3 Fettuccine à ¢-  Linguine Resembling thin, flat spaghetti and used in the same way. Figure 2.4 Linguine à ¢-  Pappardelle Broad, flat noodles, often with a wavy edge. It often made with egg pasta and is tranditionally served with meat and game sauces. Figure 2.5 Pappardelle à ¢-  Spaghetti Probably the best known of all long pastas, these long, thin strings are good with ant sauce. Spaghettini has thinner strands. Figure 2.6 Spaghetti à ¢-  Tagliatelle Flat ribbon noodles sold in nests. It may be plain or with egg or spinach. Figure 2.7 Tagliatelle à ¢-  Vermicelli Fine pasta strands, sold coiled into nests. It may be plain or with egg and is good with light sauces. Figure 2.8 Vermicelli SHORT PASTA There are even more varieties of short pasta than there are long. They are widely available fresh and dried and may be plain, with egg, or flavorued and coloured. They are favoured by many for their versatility suiting most sauces and being great in salads and baked dishes. Common varieties include: à ¢-  Conchiglie Shell-shaped and available in many different sizes from large ones for stuffing, medium ones for tossing with sauce and tiny ones for soup. Figure 3.1 Conchiglie à ¢-  Farfalle Little pasta bows, plain or flavoured with spinach or tomato. Figure 3.2 Farfalle à ¢-  Fiorelli Pretty pasta tubes with a lacy edge. Figure 3.3 Fiorelli à ¢-  Fusilli Spirals resembling tight springs, formed by wrapping dough around a thin rod. Figure 3.4 Fusilli à ¢-  Macaroni Thick, slightly curved tubes of pasta. It is particularly popular served with thick, creamy sauces and in baked dishes. Figure 3.5 Macaroni à ¢-  Pastina Tiny pasta shapes for soup. They come in a fabulous array of shapes for soup. They come in a fabulous array of shapes including stars, letters, tubes, shells, bows, rings and squares. Larger ones are good for chunky soups such as minestrone, while the tiniest are ideal for light broths. Figure 3.6 Pastina à ¢-  Penne Tubular pasta shapes with angled ends, resembling a quill. Figure 3.7 Penne à ¢-  Rigatoni Ridged, chunky tubes used in the same way as macaroni. Figure 3.8 Rigatoni à ¢-  Rotelle Shaped like tiny cartwheels, these are very popular with children. Figure 3.9 Rotelle FLAT PASTA There are many flat pasta ribbons (see long pasta, above), but there is really only one type of flat pasta sheet. à ¢-  Lasagne Usually plain or flavoured with spinach, and available dried or fresh. The most commonly available varieties require no pre-cooking. The flat or ridged sheets may be layered with sauce and baked to make classic lasagna, or cooked then rolled around a filling and baked to make cannelloni. Figure 4 Lasagne STUFFED PASTA Usually available fresh, but also dried, stuffed pasta is good served simply, tossed with butter or oil, or with smooth sauces. Common varieties include: à ¢-  Cannelloni Dried pasta tubes for stuffing yourself, then covering in sauce and baking. Figure 5.1 Cannelloni à ¢-  Cappelletti Little hat-shaped pasta shapes made from a square of pasta dough that has been filled, folded into a triangle, and the ends wrapped round to make a brim. Traditionally eaten at Christmas in broth, but also good tossed with butter or sauce. Figure 5.2 Cappelletti à ¢-  Ravioli Usually square, these stuffed cushions of pasta may be large or small. Fillings may vary, to, with meat, fish, shellfish, cheese and vegetables all being popular. Figure 5.3 Ravioli à ¢-  Tortellini Similar to cappelletti in appearance, although larger and made with dough rounds rather than squares. Like ravioli, fillings are many and varied. Figure 5.4 Tortellini COOKING PASTA Pasta, whether fresh or dried, is incredibly simple to cook as long as you follow there simple rules. 1. Always use a big pan with plenty of water. The pasta needs enough room to cook without sticking together. Allow about 5 litres of water for every 500g of pasta. If youre cooking less pasta, you should still use at least 2.75 litres of water. 2. Add enough salt to the water: pasta cooked in unsalted water will give tasteless results. Allow 1 2 tablespoons of salt for every 500g of pasta. *Dont worry if this sounds like a lot of salt; most of it will be thrown away with the cooking water. 3. Add a little oil to the water to prevent the pasta sticking together. In the case of lasagna sheets, up to a tablespoonful of oil may be needed. Bring the cooking water to a fast rolling boil before adding the pasta otherwise the pasta can become stodgy. 4. Add the pasta in one go so that it all has the same cooking time. Long pasta such as spaghetti should be placed in the boiling water, then gently pressed into the water as it softens to ensure even cooking. 5. Give the pasta a quick stir to prevent it sticking together, then quickly return the water to a roiling boil. 6. Reduce the heat to medium-high so that the water remains at a brisk boil, stirring now and again to prevent the pasta sticking. 7. The pasta is ready when it is al dente that is tender, yet still with a bite when bitten. The easiest way to check this is to remove a piece of pasta from the pan and give it a bite. If you overcook pasta, you will get soft, stodgy results. 8. As soon as the pasta is al dente, drain it well, shaking the colander or sieve to remove any excess water. Reserve 2-3 tablespoons of cooking water in case you need to loosen the pasta sauce when you combine it with the pasta. *If the pasta is to be served cold, rinse it under cold water in the colander, then set aside. 9. Serve immediately with the sauce of your choice, or add ingredients ready for baking. HOW MUCH PASTA? The quantity of pasta required per person is a slightly moveable feast, depending on appetite, whether the sauce is light or substantial, and whether youre serving the dish as an appetizer or main course. However, you can use the following dry weight as a general guide: à ¢-  for an appetizer, allow 50g (2oz) per person à ¢-  for a main meal, allow 75-125g (3-4oz) per person COOKING TIMES Accurate timing is essential for perfect pasta, and cooking times can vary according to the variety, brand and type of pasta. Always check the packet for timing, or, if youre making your own, follow the timing given in the recipe. Start timing as soon as the water returns to the boil after adding the pasta. As a general guide, use the following times: à ¢-  thin, fresh noodles 1-2 minutes à ¢-  thicker fresh noodles and pasta shapes 2-3 minutes à ¢-  stuffed fresh pasta 3-4 minutes à ¢-  dried pasta 8-12 minutes (though wholemeal may take longer). WHICH PASTA? WHAT SAUCE? Another secret to success when serving pasta is pairing the right pasta with the right sauce -synchronizing your timing so that theyre both ready at the same time. *Most sauces can stand a little waiting while the pasta finishes cooking, but pasta is best served as soon as it is cooked, so try to make sure your sauce is ready in time. Although some sauces are traditionally served with specific pastas for example fettuccine all Alfredo, bucatini all Amatriciana, and penne all Arrabiata common sense usually prevails when pairing pasta and sauces. Heavy, chunky sauces are best served with short pasta shapes, such as penne, conchiglie and rigatoni, or wide noodles, such as pappardelle and tagliatelle. The sauce doesnt slide off these pastas in the way that it would a fine, delicate pasta such as capelli dangelo. Long, thin pastas, such as spaghetti and linguine, go better with smooth sauces that cling to their length, such as tomato or creamy sauces. And delicate pastas such as vermicelli go well with light sauces, such as seafood ones. There are also classic Italian regional pairings. For example, olive oil sauces made with tomatoes and seafood, which are popular in the south, are usually served with the plain durum wheat pasta, such as spaghetti and vermicelli, that is popular in the area. In the north, however, sauces are frequently made with butter and cream, and these go very well with the egg pasta that is made there. STORAGE Fresh pasta is best eaten on the day that it is made, although it can be refrigerated for 24 hours, or frozen for up to 3 months. Ready-made, vacuum-packed varieties may be stored in the refrigerator for slightly longer, so check the advice on the packet. Once opened, dried pasta should be stored in an airtight container and used within 9 months. Figure 6 Cooking pasta steps HISTORY OF PASTA Although pasta is associated with Italian food, but researchers claim pasta to be a Chinese invention that was brought by Venetian merchant Marco Polo to Italy after his famous trip to the Middle Kingdom in the 13th century.The idea that Marco Polo brought pasta from China to Italy is as similar to Italians as the idea that the hamburger came from Germany is to Americans. No one argue that the Chinese have made pasta, from many more kinds of flour than Europeans have, since at least 1100 B.C. Italians insist as a point of national pride that they invented pasta in their part of the world, despite considerable evidence that they did not. They cite as proof a set of reliefs on an Etruscan tomb dating from the fourth century BC, which carved a knife, a board with a raised edge that resembles a modern pasta board, a flour sack, and a pin that they say was made of iron and used for shaping tubular pasta. The Museum of the History of Spaghetti, owned by Agnesi (a pasta manufacturer near Tu rin) makes much of these reliefs, as do most histories of pasta-including the standard one, Anna del Contes Portrait of Pasta. The reliefs do not persuade the American historian Charles Perry, who has written several articles on the origins of pasta. There are plenty of things to do with a pin besides shape pasta, he says. In fact, Perry says, no sure Roman reference to a noodle of any kind, tubular or flat, has turned up, and that makes the Etruscan theory even more unlikely, given that the Romans dominated Italy soon after the Etruscans did. The first clear Western reference to boiled noodles, Perry says, is in the Jerusalem Talmud of the fifth century A.D., written in Aramaic. The authors debated whether or not noodles violated Jewish dietary laws. (Today only noodles made of matzoh meal are kosher for Passover.) They used the word itriyah, thought by some scholars to derive from the Greek itrion, which referred to a kind of flatbread used in religious ceremonies. By the tenth century, it appears, itriyah in many Arabic sources referred to dried noodles bought from a vendor, as opposed to fresh ones made at home. Other Arabic sources of the time refer to fresh noodles as lakhsha, a Persian word that was the basis for words in Russian, Hungarian, and Yiddish. (By comparison with these words, noodle, which dates from sixteenth-century German, originated yesterday.) In the twelfth century an Arab geographer, commissioned by the Norman king of Sicily to write a sort of travel book about the island, reported seeing pasta bei ng made. The geographer called it itriyah, from which seems to have come trii, which is still the word for spaghetti in some parts of Sicily and is also current in the name for a dish made all over Italy-ciceri e trii, pasta and chick-pea soup. The soup reflects the original use for pasta, which was as an extender in soups and sometimes desserts. Serving pasta as a dish in itself with a bit of sauce does seem to be an Italian rather than a Greek, Persian, or Arab invention. (Classic Cuisine of the Italian Jews, a wonderful book by EddaServiMachlin, has delicious pasta recipes that show some of the many influences that the Arab world had on Italian food.) The Marco Polo myth has refused to die. Italians accuse Americans of promulgating it, beginning with an influential article in a 1929 issue of Macaroni Journal (now Pasta Journal), an American trade magazine, which has inspired countless advertisements, restaurant placemats, cookbooks, and even movies. (From 1919 on, Macaroni Journal occasionally published articles purporting to give the history of pasta, usually-though not always-labeling the less plausible ones as lore. The 1929 story began, Legend has it . . .) In the 1938 film The Adventures of Marco Polo, Gary Cooper points to a bowl of noodles and asks a Chinese man what he calls them. In our language, the man replies, we call them spa get. In the centuries after Marco Polos voyage pasta continued to be a luxury in Italy. By 1400 it was being produced commercially, in shops that retained night watchmen to protect the goods. The vermicelli, as dried pasta was known, was kneaded by foot: men trod on dough to make it malleable enough to roll out. The treading could last for a day. The dough then had to be extruded through pierced dies under great pressure, a task accomplished by a large screw press powered by two men or one horse. This somewhat gamy procedure was not used for other kinds of dough, but commercial pasta dough has never been normal dough. The flour used to make it-semolina-is granular, like sugar, and has a warm golden color. Semolina makes a straw-colored dough that must be kneaded for a long time, which is why it has always been far more common in commercial than in homemade pasta. Semolina is milled from durum wheat (Triticum durum; durum means hard), a much harder grain than common wheat (Triticumvulgarum), which is used to make ordinary flour. (The harder the grain, the more energy required to mill it.) All durum makes firmer cooked pasta than common flour does, but not all durum is alike in hardness or quality. The kind of durum milled into semolina and how a manufacturer makes and dries the dough determine the firmness of the pasta when it is cooked. Durum wheat was suited to the soil and weather of Sicily and Campania, the region around Naples, and so the pasta industry developed there, in the eighteenth century, and led Italian production into this century. Naples had a perfect climate for drying pasta. The alternation of mild sea breezes and hot winds from Mount Vesuvius ensured that the pasta would not dry too slowly, and thus become moldy, or too fast, and thus crack or break. The number of pasta shops in Naples went from sixty to 280 between the years 1700 and 1785. Young English aristocrats making the grand tour in the eighteenth century were shown the city where pasta hung everywhere to dry-in the streets, on balconies, on roofs. Neapolitan street vendors sold cooked spaghetti from stalls with charcoal-fired stoves, working with bowls of grated Romano cheese beside them. Customers would follow the example of the barkers, who lifted the long strands high and dropped them into their mouths. The grand tourists assumed that t he fork hadnt yet caught on in Italy, whereas it was the Venetians who in the sixteenth century had introduced the fork to Europe. EVOLUTION OF PASTA As we look into the history of Italian pasta cooking, we will see that the food used as a basic type of food in the Italian diet has not always been so. While till the 1500s, macaroni (the term used for any dried pasta) was considered an exotic food, cooking pasta in an Italian household was considered very expensive chiefly due to the high costs and the time-intensive labor required for making pasta and was reserved only for the upper class. However, after the 17th century, the variation of the pasta industry saw a sea-change along with rapid industrialization and technological advances, finally making Italian pasta cooking a hot favorite among all classes. For this reason, Italians embraced pasta as an essential part of their daily diet. Eventually, the diversity, distinctive flavors and unique specialty dishes originating from Italian pasta made Italian cuisine a hot favorite among the whole of Europe and America. Italian pasta of course rules the roost, being the most important o f food culture throughout all of Italy. Through the course of time, the role of Italian pasta has changed greatly throughout Italys culinary history. Once enjoyed by Italys elite as a handmade specialty, today cooking pasta is made the foundation of Italian cuisine all over the globe. Today, a large amount of Italian pasta products available in the market consist of both fresh and dried pasta and range in size from tiny soup pasta to large sheets of lasagna noodles. Furthermore, there are shaped Italian pasta available in many different sizes and specific shapes. While the basic cooking method used for cooking pasta is boiling, a few other methods are also used to cook specific types of pasta, including baking, stir-frying, and deep-frying. Accomplished with a minimal amount of equipment like a large pot, a large spoon, and a colander, Italian pasta meals are known for their flavor and paired with healthy ingredients like tomato sauce, fresh vegetables, olive oil and fish. The meal is low in fat and contains nutrients and antioxidants to nurture body as your palate. Human diet on pasta PASTA IS A MEAL Generally, pasta is a simple dish, but comes in large varieties because it is a versatile food item. Some pasta dishes are served as an appertizer in Italy because the portion sizes are small and simple. The servings are usually accompanied by a side of meat. Pasta is also can be prepared as main course, such as salads or large portion sizes for dinner. HOW DO ITALIANS EAT PASTA? They serve pasta in warm, shallow and wide bowls instead of on dinner plates. In Italy, they call this a piatto fondo or deep dish. The rims of the bowl should be just enough to spin the fork against. They dont have to use the spoon. They put smaller portions of spaghetti on their fork before start to twirl. Then, twirl the pasta with a fork keeping the fork tip in contact with the plate. By doing so, they avoid the need to slurp and the need for a bib. DO ITALIANS EAT PASTA EVERYDAY? Yes, they eat pasta every day. In Italy, pasta is the most dishes that are dressed really simple and with few ingredients. They always use fresh and natural ingredients, dress lightly and most of all dont overcook. This is because overcooked pasta sends blood sugar higher than pasta cooked al dente. Italians believe that overcooked pasta is harder to digest and doesnt leave them feeling sluggish. When pasta is overcooked, it means it has absorbed its maximum amount of liquid. On the other hand, pasta cooked al dente can still absorb more during the digestive process and therefore digests more easily. PASTA SERVING SIZE Portion size of pasta is different depending on the ways that they eat pasta: Two to four ounces dry spaghetti as an appetizer Four to six ounces for a main course WHY EAT PASTA WITH SAUCE? Pasta sauces vary in taste, color and texture. Different types of pasta are served with different types of sauce according to the general rule that must be observed. For example, simple sauces like pesto are ideal for long and thin strands of pasta while tomato sauce combines well with thicker pastas. Thicker and chunkier sauces have the better ability to cling onto the holes and cuts of short, tubular, twisted pastas. Sauce should be served equally with its pasta. It is important that the sauce does not overflow the pasta. The extra sauce is left on the plate after all of the pasta is eaten. WHY PASTA POPULAR IN ITALY? Pasta is a traditional food in Italy and it is popular because it can be made into lots of shapes and pasta dishes. People can create lots of different dishes with it. It tastes delicious and its filling. Now, it became modern cooks because it is easy to prepare and convenient. Its also has a long shelf life Commercialization of Pasta Commercialization enables manufacturers to take the right product into the right place, at the right time, to satisfy end-consumers. In fact, the commercialization of pasta could only have developed in a strongly urbanized society. Due to its ease of preparation, low cost, versatility, palatability, long shelf life, and nutritional value, pasta is a popular commercial food product. Pasta products are commonly produced by extrusion, and their main ingredients are durum wheat semolina and water. Celiac disease is an immune-mediated disease triggered by the ingestion of the protein composite gluten. The only treatment for celiac disease is the permanent exclusion of sources of gluten (wheat, rye, and barley products) from the diet. It is important that high-quality cereal products made from alternative grains are available to this segment of the population. Recently, research on the improvement and development of gluten-free pasta has enahnced. Meanwhile, the number of gluten-free pasta products available on the market has increased dramatically. Preparation of Pasta BLT PASTA SALAD (BLT Bacon, Lettuce, Tomatoes) Ingredients 250gm any spiral/corkscrew pasta (Riccioli)  ½ cup milk 200gm bacon, sliced small 200gm cherry tomatoes, halved 1 clove garlic, finely minced 1 head of cos lettuce or 5 heads of baby romaine, torn to small pieces (basicallycos lettuce or romaine is the same thing) 100gm mayonnaise 70gm natural set plain yogurt 4 tbsp chopped spring onions salt black pepper Methods 1. Cook the pasta as per instructions on packaging until al dente. Drain and mix with milk. Set aside. (toss it from time to time to distribute the milk) 2. Fry bacon in pan (no oil) until crispy and the bacon oil oozes out. Tilt pan and let the oil drain off the bacon. Dish up bacon. Set aside. 3. Pour away most of the oil in pan, leaving behind about 2-3 tbsp of it. On medium heat, sautà © garlic until fragrant and pour in the halved cherry tomatoes. Just spread in pan but dont toss them. Let it cook until the garlic is golden. Tilt pan, push tomatoes to the higher side and let the oil collect at the lower side. Dish up tomatoes and as much garlic as you can. Set aside. (the tomatoes should not be mushy, but just cooked) 4. Prepare salad dressing, mix everything together and sprinkled the final 1 tbsp of spring onion as garnish. BAKED PASTA Ingredients 400gm pasta (shell pasta) 2 tbsp butter 2 tbsp oil 1 large onion, diced 3 cloves garlic, roughly chopped 400gm beef, minced 4 tbspchilli Paste 1 large carrot, diced 2 tomatoes, roughly chopped 1  ½ c peas 4 eggs, beaten 1 c cheddar, grated A handful of fried scallions A handful of parsley, chopped Salt sugar for seasoning Method 1. Cook pasta in a pot of boiling water until 2/3 cooked. Season with salt. Drain and set aside. 2. Then, heat wok with oil and butter. 3. Cook onion until soft and slightly caramelized. 4. Add in garlic. 5. Add the beef and cook until slightly brown. 6. Add chili paste and cook until the oil starts to bubble on the surface. 7. Add in carrot and stir well until slightly soft. 8. Add in tomatoes and let it cook until soft. Then mix in the pasta. 9. Switch the heat off, add parsley and season well with salt and sugar. 10. Make a well in the center of the wok and pour in beaten eggs. Let it scramble and stir to mix. 11. Combine the ingredients well. 12. Put the combined ingredients in a casserole dish. 13. Sprinkle the cheese and fried scallions evenly over the top of the mixture and bake at 150oC for 20-25 mins. GREEK MEAT PASTA Ingredients 1 package rotini pasta (16 ounce) 3 tbsp olive oil, divided 1 pound ground beef 6 tomatoes, grated 1 sweet yellow onion, grated  ½cup water 3 tbsp tomato paste 1 tbsp ground cinnamon  ½tsp white sugar  ½tsp cayenne pepper Salt ground black pepper to taste 4 cups shredded Mizithra cheese 1 cup shredded mozzarella cheese Method 1. Bring a large pot of lightly salted water to a boil; cook the rotini at a boil until tender yet firm to the bite, about 8 minutes; drain. Transfer to a large bowl and toss with 2 tablespoons olive oil. 2. Heat 1 tablespoon olive oil in a large skillet over medium heat; cook and stir ground beef until browned, about 10 minutes. Add tomatoes, onion, water, tomato paste, cinnamon, sugar, cayenne, salt, and pepper; stir to combine. Simmer meat sauce over medium-low heat until flavors combine, 20 minutes. 3. Preheat oven to 350 o F (175 oC). 4. Pour meat sauce over rotini; mix well. Pour half the pasta mixture into a casserole dish; sprinkle with half the Mizithra cheese and half the mozzarella cheese. Top with remaining pasta mixture; sprinkle remaining Mizithra cheese and mozzarella cheese. 5. Bake in the preheated oven until cheese is melted and bubbling, about 40 minutes. SEAFOOD PASTA Ingredients Spaghetti 10 medium-sized prawns, peeled and deveined 2 handful of clams 4 pcs of frozen fish cocktail 1 can of tomato pasta sauce 4 cloves of garlic, finely chopped 50ml water 3 tbsp olive oil Method 1. Bring a pot of water to a boil. Cook the spaghetti exactly according to the packet instruction. Drain and set aside. 2. Oven-baked the fish cocktail as per the packaging instruction. Cook and set aside. 3. Heat some olive oil in a sauce pan. Sautà © the garlic till fragrant. Add the clams and prawns to stir-fry for 1 minute. 4. Pour in the pasta sauce and water. Cook and stirring for 2 minutes. 5. Toss with spaghetti and serve with baked fish cocktails. MUSHROOM PASTA WITH TRUFFLE OIL (vegetarian) Ingredients 200g pasta (I prefer to use spaghetti or angel hair pasta) 100g grey oyster mushrooms, sliced thinly A handful of cep mushrooms, soaked and chopped roughly (optional) 2-3 tbsp extra virgin olive oil 3-4 cloves of garlic, finely chopped Salt and freshly ground pepper Fresh parsley, finely chopped Truffle oil Egg (optional) Method 1. Bring a pot of salted water to boil and cook pasta according to pack instructions (al dente should take about 8-10 minutes). Remove from heat and drain, run under cold water to stop from cooking further. 2. Heat olive oil in frying pan on medium high heat. Add garlic and cook for 2 minutes until golden brown, then add the mushrooms and fry for 1-2 minutes until cooked. 3. Finally add the pasta, parsley and mix thoroughly, and then season with salt and pepper. 4. Remove from heat and serve immediately. Add a dash of truffle oil to finish. Significance of Pasta

What Happened to Disco? Essay -- essays research papers

What happened to Disco? Bellbottoms, afros, music, sex and drugs can best describe the Disco Era. The Disco Era was a care-free time in which there were no rules. People danced the nights away. Most of the people of the Disco Era lived normal lives, working nine to five jobs during the week, but when the weekend rolled around they put on their bellbottoms and dancing shoes and hit up the Disco Clubs. This is an era that will never be forgotten but will probably never be relived. Disco is said to have begun in the gay nightclubs of New York City in the mid 1960's. At these clubs Deejays played records from little known black artists and quickly and accidentally began channeling underground music to the population. This quickly caught the attention of major record production companies. Up until this point in time, deejays didn't get very much respect for their profession. Disk Jockeys began to play a major role, and soon they became celebrities, in the entertainment world. The whole idea to "Disco Music" was mixing recorded music with other forms of music. This included mixing it with live music as well as mixing it with other recorded tracks. As this type of sound became very popular, recording artists started mixing different types of music in the recording studio. There were so many popular artists during the Disco Era, and much of their music is still listened to today. One particular group that gained much fame during this era was the Bee Gees. When the Bee Gees first came out their popularity skyrocketed. They were said by many to be the next Beatles only with a different type of music. Those who did characterize them as the next Beatles were exactly right. They produced number one hits one after the other. Some of their biggest hits were placed on the soundtrack to Saturday Night Fever, which became the biggest selling album in history up to that point. Saturday Night Fever, starring John Travolta, was a movie based on the life of Disco. John Travolta became a cultural Icon to young males during the 70's. Every guy dressed like him and wanted to live like him, and every female wanted to date him. This movie became one of the biggest influences on disco goers of this era. Before this movie came out, disco was very popular. After the re lease of the mo... ...because they acted like themselves. They didn't feel as though they had to be "Politically Correct" anymore. They went out and did what they wanted to do, when they wanted to do it, including, the chronic drug use and the careless sex. The sad thing about the Disco era is, although it will always be a part of our culture as a nation but it will never make a comeback. Sure, people still wear bellbottoms, and there are still hippies and disco music is still very popular, but the United States has become too modernized for the disco era to ever make a comeback. Personally, I think that it would be very cool if it were to make a comeback. I think that it would be fun to wear bellbottoms and crazy shirts, but I'm sure that I would get sick of it very quickly and go back to the way that I am used to living. First of all, the music industry would never allow for new disco acts to burst upon the scene. The music industry is what got the era going in the first place. Secondly, the United States government would never allow for such an era to occur again. The Disco Era will always play a very important role in the history of the United States and will forever live on in spirit.

Smu Solved Assignments

MB0044 – Production & Operations Management Assignment set – 1 1. What are the components of systems productivity? Explain how CAD and CIM help in improving productivity. Production management encompasses all activities which go into conversion of a sate of inputs into outputs which are useful to meet human needs. It involves the identification of the perquisite materials, knowledge of the processes, and installation of equipments necessary to convert or transform the materials to products. System productivity is generally expressed as the ratio of outputs to inputs.Productivity can be calculated for a single operation, a functional unit, a department division or a plant. It is a measure of the efficiency of the system and looks at the economies achieved during the processes. Every process will have number of contributors-people machines, facilitating goods, ancillary equipments, technology, etc. Which help in achieving maximum productivity – each element attempt ing to enhance the contribution of other elements? Enhancement of productivity is achieved by either reducing the inputs for the same output or increasing the output by using the same input. Opportunities exist at all stages of the workflow.The entire system of introduce measures for increasing productivity. However in actual manufacturing situations, the inefficiencies will have cascading effect in hampering productivity. Communication, effective review processes and innovative methods will ensure optimization of resources. Capital productivity: Capital deployed in plant, machinery, buildings and the distribution system as well as working capital are components of the oust of manufacture and need to be productive. Demand fluctuations, uncertainties of production owing to breakdowns and inventories being crated drag the productivity down.Therefore, strategies are needed to maximize the utilization of the funds allotted towards capital. Adapting to new technologies, outsourcing and b alancing of the workstations to reduce the proportion of idle times on equipments are the focus of this section. Computers in design and manufacturing applications make it possible to remove much of the tedium and manual labor involved. For example, the many design specifications, blueprints, material lists, and other documents needed to build complex machines can require thousands of highly technical and accurate drawings and charts.If the engineers decide structural components need to be changed, all of these plans and drawings must be changed. Prior to CAD/CAM, human designers and draftspersons had to change them manually, a time consuming and error-prone process. When a CAD system is used, the computer can automatically evaluate and change all corresponding documents instantly. In addition, by using interactive graphics workstations, designers, engineers, and architects can create models or drawings, increase or decrease sizes, rotate or change them at will, and see results inst antly on screen.CAD is particularly valuable in space programs, where many unknown design variables are involved. Previously, engineers depended upon trial-and-error testing and modification, a time consuming and possibly life-threatening process. However, when aided by computer simulation and testing, a great deal of time, money, and possibly lives can be saved. Besides its use in the military, CAD is also used in civil aeronautics, automotive, and data processing industries. CAM, commonly utilized in conjunction with CAD, uses computers to communicate instructions to automated machinery.CAM techniques are especially suited for manufacturing plants, where tasks are repetitive, tedious, or dangerous for human workers. Computer integrated manufacturing (CIM), a term popularized by Joseph Harrington in 1975, is also known as Autofacturing. CIM is a programmable manufacturing method designed to link CAD, CAM, industrial robotics, and machine manufacturing using unattended processing wo rkstations. CIM offers uninterrupted operation from raw materials to finished product, with the added benefits of quality assurance and automated assembly. 2. What do you understand by ‘industry best practice’?Briefly explain different types of Benchmarking. Industry best practice: Each industry would have developed over years or decades. Materials would have changed, processes would have changed. As all products or services are meant to serve needs of the customers, they undergo continuous changes – both in shapes and features. Because of research that is conducted, materials and methods go on improve incessarily. The companies that were at the force innovate to stay in business as new entrants would be adopting the latest techniques that the pioneers had taken decades to establish.So the practices adopted by various firms in any industry would end up adopting almost similar methods of getting an output required. Such practices would get refined to great extent giving rise what we call industry best practices. These tend to get stabilized or changed owning to the development of new equipments which are designed and manufacturers of those with an eye on growing markets which demand higher quality and reduced prices. Competition benefits those who can use all these to their advantage. Industry best practices open up the field for benchmarking by companies which need to improve their performance.Bench Marking: It is a method of measuring a company’s processes, methods, procedures and in a way all functions in great detail. Benchmarking is used to understand how these got into the system and what circumstances brought them about. It is a learning process with a few to find out whether some of the reasons have changed and bring in new processes for improvement.. The metrics that could be used are – number of pieces per hour, cost per unit, number of breakdowns per week, customer alienation during a week, return on investment, numb er of returns from customers in a month, inventory turnover, and many others.As can be seen the figures as found above determine the efficiency of the organisation. To keep focused, many organizations, especially the large ones, select a few processes for purposes of benchmarking. This helps in ensuring constant and deep attention to those aspects which are to be dealt with. The following are the types of benchmarking firms consider. Types of benchmarking: †¢ Process benchmarking – the initiating firm focuses its observation and investigation of business processes with a goal of identifying and observing the best practices from one or more benchmark firms.Activity analysis will be required where the objective is to benchmark cost and efficiency; increasingly applied to back-office processes where outsourcing may be a consideration. †¢ Financial benchmarking – performing a financial analysis and comparing the results in an effort to assess your overall competi tiveness and productivity. †¢ Benchmarking from an investor perspective- extending the benchmarking universe to also compare to peer companies that can be considered alternative investment opportunities from the perspective of an investor. Performance benchmarking – allows the initiator firm to assess their competitive position by comparing products and services with those of target firms. †¢ Product benchmarking – the process of designing new products or upgrades to current ones. This process can sometimes involve reverse engineering which is taking apart competitors products to find strengths and weaknesses. †¢ Strategic benchmarking – involves observing how others compete. This type is usually not industry specific, meaning it is best to look at other industries. Functional benchmarking – a company will focus its benchmarking on a single function to improve the operation of that particular function. Complex functions such as Human Resour ces, Finance and Accounting and Information and Communication Technology are unlikely to be directly comparable in cost and efficiency terms and may need to be disaggregated into processes to make valid comparison. †¢ Best-in-class benchmarking – involves studying the leading competitor or the company that best carries out a specific function. Operational benchmarking – embraces everything from staffing and productivity to office flow and analysis of procedures performed. 3. List out the various automated systems for transfer of materials in the production plant. What do you understand by Line Balancing? Explain with an example. About the automated flow lines we can say it is a machine which is linked by a transfer system which moves the parts by using handling machines which are also automated, we have an automated flow line. Human intervention ma is needed to verify that the operations ate taking place according to standards.When these can be achieved with the h elp of automation and the processes are conducted with self regulation, we will have automated flow lines established. In fixed automation or hard automation, where one component is manufactured using services operations and machines it is possible to achieve this condition. We assume that product life cycles are sufficiently stable to interest heavily on the automate flow lines to achieve reduces cast per unit. Product layouts ate designed so that the assembly tasks are performed in the sequence they are designed at each station continuously.The finished item came out at the end of the line. In automated assembly lines the moving pallets move the materials from station to station and moving arms pick up parts, place them at specified place and system them by perusing, riveting, & crewing or even welding. Sensors will keep track of their activities and move the assembles to the next stage. The machines are arranged in a sequence to perform operations according to the technical requi rements. The tools are loaded, movements are effected, speeds controlled automatically without the need for worker’s involvement.The flexibility leads to better utilization of the equipments. It reduces the numbers of systems and rids in reduction of investment as well as a space needed to install them. One of the major cancers of modern manufacturing systems is to be able to respond to market demands which have uncertainties. Prototyping is a process by which a new product is developed in small number so as to determine the suitability of the materials, study the various methods of manufactured, type of machinery required and develop techniques to over come problems that my be encountered when full scale manufacture is undertaken.Prototypes do meet the specification of the component that enters a product and performance can be measured on these. It helps in con be reforming the design and any shortcomings can be rectified at low cost. Flexibility has three dimensions in the manufacturing field. They are variety, volume and time. There demands will have to be satisfied. In that sense they become constraints which restrict the maximization of productivity. Every business will have to meet the market demands of its various products in variety volumes of different time.Flexibility is also needed to be able to develop new products or make improvements in the products fast enough to cater to shifting marker needs. Manufacturing systems have flexibility built into them to enable organization meet global demand. You have understood how the latest trends in manufacturing when implemented help firms to stay a head in business. 4. Explain the different types of Quality Control Tools with examples? How do Crosby’s absolutes of quality differ from Deming’s principles?Quality Control (QC) is a system of routine technical activities, to measure and control the quality of the inventory as it is being developed. The QC system is designed to: Provide routi ne and consistent checks to ensure data integrity, correctness, and completeness; Identify and address errors and omissions; Document and archive inventory material and record all QC activities. The following seven are considered basic tools for achieving quality. Flow Chart Check sheet Histogram Pareto Analysis Scatter Diagram Control Chart Cause and Effect Diagram Flow Chart It is a visual representation of process showing the various steps.It helps in locating the points at which a problem exists or an improvement is possible. Detailed data can be collected, analyzed and methods for correction can be developed. A sample is shown below lists out the various steps or activities in a particular job. It classifies them as a procedure or a decision. Each decision point generates alternatives. Criteria and Consequences that go with decision are amenable to evaluation for purposes of assessing quality. The flow chart helps in pin-pointing the exact at which errors have crept in. A simpl e chart is shown below. Check SheetThese are used to record the number of defects, types of defects, locations at which they are occurring, times at which they are occurring, workmen by whom they are occurring. It keeps a record of the frequencies of occurrence with reference to possible defect causing parameter. It helps to implement a corrective procedure at the point where the frequencies are more, so that the benefit of correct will be maximum. A sample sheet is shown below. Histogram Histograms are graphical representations of distribution of data. They are generally used to record huge volumes of data about a process.They reveal whether the pattern of distribution – whether there is a single peak, or many peak and also the extent of variation around the peak value. This helps in identifying whether the problem is serious. When used in conjunction with comparable parameters, the visual patterns help us to identify the problem which should be attended to. Pareto Analysis This is a tool for classifying problem areas according to the degree of importance and attending to the most important. Pareto principle, also called 80-20 rule, states that 80 percent of the problems that we encounter arise out of 20 percent of items.If we find that, in a day, we have 184 assemblies have given problems and there are 11 possible causes, it is observed that 80 per cent of them i. e. 147 of them have been caused by just 2 or 3 of them. It will be easy to focus on these 2 or three and reduce the number of defects to a great extent. When the cause of these defects have been attended, we will observe that some other defect Scatter Diagram These are used when we have two variables and want to know the degree of relationship between them. We can determine if there is cause and effect relationship between and its extent over a range of values.Sometimes, we can observe that there is no relationship, in which we can change one parameter being sure that it has no effect on the other parameter. Control Charts These are used to verify whether a process is under control. Variables when they remain within a range will render the product maintain the specifications. This is the quality of conformance. The range of permitted deviations is determined by design parameters. Samples are taken and the mean and range of the variable of each sample (subgroup) is recorded. The mean of the means of the samples gives the control lines. Assuming normal distribution, we expect 99. 7 per cent of all values to lie within the UCL when we take 3 standard deviations – Upper Control Limit – and LCL – Lower Control Limit. The graphical representation of data helps in changing settings to bring back the process closer to the target. Cause and Effect Diagram This is a diagram in which all possible causes are classified on quality characteristics which lead to a defect. These are arranged in such a way that different branches — the causes are – le ading the stem in the direction of the discovery of the problem. When each of them is investigated thoroughly we will be able to pinpoint some factors which cause the problem.We will also observe that a few of them will have cumulative effect or even a cascading effect. Deming Wheel Deming’s approach is summarized in his 14 points. Constancy of purpose for continuous improvement Adopt the TQM philosophy for economic purposes Do not depend on inspection to deliver quality Do not award any business based on price alone Improve the system of production and service constantly Conduct meaningful training on the job Adopt modern methods of supervision and leadership Remove fear from the minds of everyone connected with the organisation Remove barriers between departments and peopleDo not exhort, repeat slogans and put up posters. Do not set up numerical quotas and work standards Give pride of workmanship to the workmen Education and training to be given vigorously State and exhibit top management’s commitment for quality and productivity Using the above principles, Deming gave a four step approach to ensure a purposeful journey of TQM. The slope is shown to indicate that if efforts are let up the program will roll back Plan – means that a problem is identified, processes are determined and relevant theories are checked out. Do – means that the plan is implemented on a trial basis.All inputs are correctly measured and recorded. Check/Study/Analyze – means that the trials taken according to the plan are in accordance with the expected results. Act – When all the above steps are satisfactory regular production is started so that quality outcomes are assured Crosby’s Absolutes of Quality Like Deming, he also lays emphasis on top management commitment and responsibility for designing the system so that defects are not inevitable. He urged that there be no restriction on spending for achieving quality. In the long run, main taining quality is more economical rather than compromising on its achievement.His absolutes can be listed as under. Quality is conformance to requirements – not ‘goodness’. Prevention, not appraisal, is the path to quality. Quality is measured as the price paid for non-conformance and as indexes. Quality originates in all factions – not quality department. There are no quality problems people, design, process create problems. Crosby also has given 14 points similar to those of Deming. His approach emphasizes on measurement of quality, increasing awareness, corrective action, error cause removal and continuously reinforcing the system, so that advantages derived are not lost over time.He desires that the quality management regimen should improve the overall health of the organization and prescribed a vaccine. The ingredients are: Integrity – honesty and commitment to produce everything right first time, every time. Communication – Flow of inf ormation between departments, suppliers, customers – helps in identifying opportunities. Systems and operations – These should bring in a quality environment – so that nobody is comfortable with anything less than the best. 5. Define project cycle, project management, and scope of project. List the various project management knowledge areas?What are the reasons for failure of a project? Project Cycle – A project cycle basically consists of the various activities of operations, resources and the limitations imposed on them. Definition of â€Å"Project Management† It is the practice of controlling the use of resources, such as cost, time, manpower, hardware and software involved in a project, that start with a problem statement and end with delivery of a complete product. Project management involves understanding its scope and various processes in the project cycle. Project Management DefinitionAs per PMBOK (Project Management — Body of Knowle dge, defined by PMI – Project Management Institute) : â€Å"Project management is the application of knowledge, skills, tools and techniques to project activities to meet project requirements. As per DIN 69901 (German Organization for Standardization): â€Å"Project management is the complete set of tasks, techniques, tools applied during project execution† Scope – It refers to the various parameters that affect the project in its planning, formulation and executions, Like:- The range of one's perceptions, thoughts, or actions.Breadth or opportunity to function. See Synonyms at room. The area covered by a given activity or subject. See Synonyms at range. The length or sweep of a mooring cable. Informal A viewing instrument such as a periscope, microscope, or telescope. Before knowing the reasons of failure we have to know about project. Project is a set of activities which are networked in order and aimed towards achieving goal of a project. Now, the reasons ar e project failure: Incidence of Project failure Projects being initiated of random at all levels Project objective not in line with business objectiveProject management not observed Project manager with no prior experience in the related project Non- dedicated team Lack of complete support from clients Factors contributing to project success not emphasized: Project objective in alignment with business objective Working within the framework of project management methodology Effective scoping planning, estimation, execution, controls and reviews, project bottlenecks Communication and managing expectations effectively with clients, team merits and stake holders Prior expectance of PM in a similar projectOverview of information and communication Technologies (ICT) project: Involve information and communication technologies such as the word wide web, e-mail, fiber-optics satellites. ii) Enable societies to produce, access, adapt and apply information in greater amount, more rapidly and a t reduce casts. iii) Offer enormous opportunities for enhancing business and economic viability. iv) Common problems encountered during projects. v) No prioritization of project activity from an organizational position. vi) One or more of the stages in the project mishandled. vii) Less qualified non-dedicated manpower. iii) Absence of smooth flow of communication between the involved parties. These basic reasons lead a project to failures. In the project failures business management and project management is directly involved. From the management point of view it is basic things to care above topics to success of a project. Project is the core business of a company. 6. Explain the various phases in project management life cycle. Explain the necessity and objectives of SCM. This is the initial phase of any project. In this phase information is collected from the customer pertaining to the project and the requirements are analyzed.The entire project has to be planned and it should be done in a strategic manner. The project manager conducts the analysis of the problem and submits a detailed report to the top project justification, details on what the problem is a method of solving the problem, list of the objectives to be achieved, project budget and the success rate of completing the project. The report must also contain information and the project feasibility, and the risks involved in the project. Project management life cycle is the integrated part of management. It is attach with project responsibility or failure of a project.The important tasks of this phase are as follows: Specification Requirements Analysis (SRA): It has to be conducted to determine the essential requirements of a project in order to achieve the target. Feasibility study: To analyze whether the project is technically, economically and practically feasible to be undertaken. Trade off analysis: To understand and examine the various alternatives which could be considered. Estimation: To esti mate the project cost, effort requires for the project and functionality of various process in the project. System design: Choose a general design that can fusil the requirements.Project evolution: Evaluate the project in terms of expected profit, cost and risks involved marketing phase. A project proposal is prepared by a group of people including the project manager. This proposal has to contain the strategies adopted to market the product to the customers. Design phase: This phase involves the study of inputs and outputs of the various project stages. Execution phase: In this phase the project manager and the teams members work on the project objectives as per the plan. At every stage during the execution reports are prepared. Control: Inspecting, Testing and Delivery phase during this phase.The project team works under the guidance of the project manager. The project manager has to ensure that the team working under his, implements the project designs accurately, the project man ager has to ensure ways of managing the customer, perform quality control work. Closure and post completion analysis phase upon satisfactory completion and delivery of the intended product or service the staff performance has to be evaluated. Document the lessons from the project. Prepare the reports on project feedback analysis followed by the project execution report. The phase which involve in the above are:The preparation stage involves the preparation and approval of project outline, project plan and project budget. The next stage involves selecting and briefing the project team about the proposals followed by discussions on the roles and responsibility of the project member and the organization. The project management life cycle: A Life cycle of a project consists of the following: Understanding the scope of the project Establishing objectives of the project Formulating and planning various activities Project execution and Monitor and control the project resources. Risk Manage ment:-Risk is defined in ISO 31000 as the effect of uncertainty on objectives (whether positive or negative). Risk management can therefore be considered the identification, assessment, and prioritization of risks followed by coordinated and economical application of resources to minimize, monitor, and control the probability and/or impact of unfortunate events or to maximize the realization of opportunities. Risks can come from uncertainty in financial markets, project failures, legal liabilities, credit risk, accidents, natural causes and disasters as well as deliberate attacks from an adversary.Several risk management standards have been developed including the Project Management Institute, the National Institute of Science and Technology, actuarial societies, and ISO standards. Methods, definitions and goals vary widely according to whether the risk management method is in the context of project management, security, engineering, industrial processes, financial portfolios, actua rial assessments, or public health and safety. The strategies to manage risk include transferring the risk to another party, avoiding the risk, reducing the negative effect of the risk, and accepting some or all of the consequences of a particular risk.Certain aspects of many of the risk management standards have come under criticism for having no measurable improvement on risk even though the confidence in estimates and decisions increase. Necessity and objectives of SCM:- SCM is the abbreviation of supply chain Management. It is considered by many express worldwide as the ultimate solution towards efficient enterprise management. SCM is required by and enterprise as a tow to enhance management effectiveness with a following organizational objective: Reduction of inventory:-Enactment in functional effectiveness of existing systems like ERP, Accounting.Software and Documentation like financial reports statements ISO 9000 Documents etc. Enhancement of participation level and empowerm ent level:- Effective integration of multiple systems like ERP, communication systems, documentation system and secure, Design R systems etc. Better utilization of resources- men, material, equipment and money. Optimization of money flow cycle within the organization as well as to and from external agencies. Enhancement of value of products, operations and services and consequently, enhancements of profitability.Enhancement of satisfaction level of customer and clients, supporting institutions, statutory control agencies, supporting institutions, statutory control agencies, suppliers and vendors, employees and executives . Enhancement of flexibility in the organization to help in easy implementation of schemes involving modernization, expansion and divestment, merges and acquisitions Enhancement of coverage and accuracy of management information systems. With the objectives of SCM its implementation are required.Implementation is in the form of various functional blocks of an organi zation interpenetrated through which a smooth flow of the product development is possible. A relatively new SCM option involves web based software with a browser interface. Several electronic marketplaces for buying and selling goods and materials. Steps involved in the implementation of SCM:- There is many steps which involved in SCM implementation are- Business Process, sales and marketing.Logistics, costing, demand planning, trade- off analysis, environmental requirement, process stability, integrated supply, supplier management, product design, suppliers, customers, material specifications, etc. Some important aspect of SCM- The level of competition existing in the market and the impact of competitive forces on the product development. Designing and working on a strategic logic for better growth through value invention. Working out new value curve in the product development along with necessary break point. Using it to analyze markets and the economies in product design.Time, cu stomer, quality of product and the concept of survival of fittest. Steps of SCM principals: Group customer by need: Effective SCM groups, customer by tie tinct service meets those particular segment. Customize the logistics networks: In designing their logistics network, companies need to focus on the service requirement and profit potential of the customer segments identified. Listen to signals of market demand and plan accordingly- sales and operations planners must monitor the entire supply chain to detect early warning signals of changing customer demand and needs.Differentiate the product closer to the customer: companies today no longer can afford to stock pile inventory to compensate for possible forecasting errors, instead, they need to postpone product differentiation in the manufacturing. Process closer to actual customer demand. Strategically manage the source of supply: by working closely with their key suppliers to reduce the overall casts of owning materials and servic es; SCM maximizes profit margins both for themselves, and their supplies.Develop a supply chain wide technology strategy: as one of the cornerstones of successful SCM information technology must be able to support multiple levels of decision making. Adopt channel spanning performance measures- Excellent supply performance measurement systems do more than just monitor internal functions. They apply performance criteria that embrace bathe service and financial metrics, including as such as each accounts true profitability. MB0045 – Financial Management Assignment set – 1 Q. 1 Write the short notes on 1. Financial management 2. Financial planning 3. Capital structure 4. Cost of capital 5. Trading on equity.Ans: 1. Financial Management Financial Management is Planning, directing, monitoring, organizing, and controlling of the monetary resources of an organization. The management of the finances of a business / organization in order to achieve financial objectives. Financia l Management is the efficient and effective planning and controlling of financial resources so as to maximize profitability and ensuring liquidity for an individual(called personal finance), government(called public finance) and for profit and non-profit organization/firm (called corporate or managerial finance). Generally, it involves balancing risks and profitability.The decision function of financial management can be divided into the following 3 major areas: INVESTMENT DECISION 1. Determine the total amount of assets needed by a firm hence closely tied to the allocation of funds 2. Two type of investment decisions namely: †¢ Capital Investment decisions re: large sums, non routine, longer term, critical to the business like purchase of plant and machinery or factory †¢ Working Capital Investment decisions re: more routine in nature, short term but are also very critical decisions like how much and how long to invest in inventories or receivables   FINANCING DECISION . After deciding on the amount and type of assets to buy, the financial manager needs to decide on HOW TO FINANCE these assets with the sources of fund 2. Financing decisions for example: †¢ Whether to use external borrowings/debts or share capital or retained earnings †¢ Whether to borrow short, medium or long term †¢ What sort of mix – all borrowings or part debts part share capital or 100% share capital †¢ The needs to determine how much dividend to pay out as this will directly affects the financial decision.Financial Planning Financial Planning is an exercise aimed to ensure availability of right amount of money at the right time to meet the individual’s financial goals Concept of Financial Planning Financial Goals refer to the dreams of the investor articulated in financial terms. Each dream implies a purpose, and a schedule of funds requirements for realising the purpose Asset Allocation refers to the distribution of the investor’s wea lth between different asset classes (gold, property, equity, debt etc. Portfolio Re-balancing is the process of changing the investor’s asset allocation Risk Tolerance / Risk Preference refers to the appetite of the investor for investment risk viz. risk of loss Financial Plan Is a road map, a blue print that lists the investors’ financial goals and outlines a strategy for realising them Quality of the Financial Plan is a function of how much information the prospect shares, which in turn depends on comfort that the planner inspires Capital Structure Capital structure of a firm is a reflection of the overall investment and financing strategy of the firm.Capital structure can be of various kinds as described below: – Horizontal capital structure: the firm has zero debt component in the structure mix. Expansion of the firm takes through equity or retained earnings only. – Vertical capital structure: the base of the structure is formed by a small amount of e quity share capital. This base serves as the foundation on which the super structure of preference share capital and debt is built. – Pyramid shaped capital structure: this has a large proportion consisting of equity capita; and retained earnings. Inverted pyramid shaped capital structure: this has a small component of equity capital, reasonable level of retained earnings but an ever-increasing component of debt. SIGNIFICANCE OF CAPITAL STRUCTURE: – Reflects the firm’s strategy – Indicator of the risk profile of the firm – Acts as a tax management tool – Helps to brighten the image of the firm. FACTORS INFLUENCING CAPITAL STRUCTURE: – Corporate strategy – Nature of the industry – Current and past capital structure Cost of Capital Cost of capital is the rate of return the firm requires from investment in order to increase the value of the firm in the market place.In economic sense, it is the cost of raising funds required to finance the proposed project, the borrowing rate of the firm. Thus under economic terms, the cost of capital may be defined as the weighted average cost of each type of capital. There are three basic aspects about the concept of cost 1. It is not a cost as such: The cost of capital of a firm is the rate of return which it requires on the projects. That is why; it is a ‘hurdle’ rate. 2. It is the minimum rate of return: A firm’s cost of capital represents the minimum rate of return which is required to maintain at least the market value of equity shares. . It consists of three components. A firm’s cost of capital includes three components a. Return at Zero Risk Level: It relates to the expected rate of return when a project involves no financial or business risks. b. Business Risk Premium: Business risk relates to the variability in operating profit (earnings before interest and taxes) by virtue of changes in sales. Business risk premium is determined b y the capital budgeting decisions for investment proposals. c. Financial Risk Premium: Financial risk relates to the pattern of capital structure (i. e. debt-equity mix) of the firm, In general, a firm which has higher debt content in its capital structure should have more risk than a firm which has comparatively low debt content. This is because the former should have a greater operating profit with a view to covering the periodic interest payment and repayment of principal at the time of maturity than the latter. Trading on Equity When a co. uses fixed interest bearing capital along with owned capital in raising finance, is said â€Å"Trading on Equity†. (Owned Capital = Equity Share Capital + Free Reserves )Trading on equity represents an arrangement under which a company uses funds carrying fixed interest or dividend in such a way as to increase the rate of return on equity shares. It is possible to raise the rate of dividend on equity capital only when the rate of intere st on fixed – interest – bearing – security is less than the rate of return earned in business. †¢Two other terms: †¢Trading on Thick Equity :-  When borrowed capital is less than owned capital †¢Trading on Thin Equity :-  When borrowed capital is more than owned capital, it is called Trading on thin Equity.Q. 2 a. Write the features of interim divined and also write the factors (08 Marks) Influencing divined policy? b. What is reorder level? Ans: a) Usually, board of directors of  company  declares  dividend  in annual general meeting after finding the real net profit position. If boards of directors give dividend for current year before closing of that year, then it is called interim dividend. This dividend is declared between two annual general meetings. Before declaring interim dividend, board of directors should estimate the net profit which will be in future.They should also estimate the amount of  reserves  which will deduct from net profit in  profit and loss appropriation account. If they think that it is sufficient for operating of business after declaring such dividend. They can issue but after completing the year, if profits are less than estimates, then they have to pay the amount of declared dividend. For this, they will have to take loan. Therefore, it is the duty of directors to deliberate with financial consultant before taking this decision.Accounting treatment of interim dividend in final accounts of company:- # First Case  : Interim dividend is shown both in profit and loss appropriation account and balance sheet , if it is outside the  trial balance  in given question. ( a) It will go to debit side of profit and loss appropriation account (b) It will also go to current liabilities head in liabilities side. # Second Case:  Interim dividend is shown only in profit and loss appropriation account, if it is shown in trial balance. ( a) It will go only to debit side of profit and loss appropriation account.If in final declaration is given outside of trial balance and this will be proposed dividend and interim dividend in trial balance will be deducted for writing proposed dividend in profit and loss appropriation account and balance sheet of company, because if we will not deducted interim dividend, then it will be double   deducted from net profit that is wrong and error shows when we will   match balance sheets assets with liabilities. Factors affecting dividend policy. The dividend decision is difficult decision because of conflicting objectives and also because of lack of specific decision-making techniques.It is not easy to lay down an optimum dividend policy which would maximize the long-run wealth of the shareholders. The factors affecting dividend policy are grouped into two broad categories. 1. Ownership considerations 2. Firm-oriented considerations Ownership considerations:  Where ownership is concentrated in few people, there are no problems in identifying ownership interests. However, if ownership is decentralized on a wide spectrum, the identification of their interests becomes difficult. Various groups of shareholders may have different desires and objectives.Investors gravitate to those companies which combine the mix of growth and desired dividends. Firm-oriented considerations:  Ownership interests alone may not determine the dividend policy. A firm’s needs are also an important consideration, which include the following: †¢ Contractual and legal restrictions †¢ Liquidity, credit-standing and working capital †¢ Needs of funds for immediate or future expansion †¢ Availability of external capital. †¢ Risk of losing control of organization †¢ Relative cost of external funds †¢ Business cycles †¢ Post dividend policies and stockholder relationships.The following factors affect the shaping of a dividend policy: Nature of Business:  Companies with unstable earnings adopt dividend policies which are different from those which have steady earnings. Composition of Shareholding:  In the case of a closely held company, the personal objectives of the directors and of a majority of shareholders may govern the decision. To the contrary, widely held companies may take a dividend decision with a greater sense of responsibility by adopting a more formal and scientific approach. Investment Opportunities:  Many companies retain earnings to facilitate planned expansion.Companies with low credit ratings may feel that they may not be able to sell their securities for raising necessary finance they would need for future expansion. So, they may adopt a policy for retaining larger portion of earnings. Similarly, is a company has lucrative opportunities for investing its funds and can earn a rate which is higher than its cost of capital, it may adopt a conservative dividend policy. Liquidity:  This is an important factor. There are companies, which are profitable but cannot generate sufficient cash, since profits are to be reinvested in fixed assets and working capital to boost sales.Restrictions by Financial Institutions:  Sometimes financial institutions which grant long-term loans to a company put a clause restricting dividend payment till the loan or a substantial part of it is repaid. Inflation:  In period of inflation, funds generated from depreciation may not be adequate to replace worn out equipment. Under inflationary situation, the firm has to depend upon retained earnings as a source of funds to make up for the shortfall. Consequently, the dividend pay out ratio will tend to be low. Other factors:  Age of the company has some effect on the dividend decision.The demand for capital expenditure, money supply, etc. , undergo great oscillations during the different stages of a business cycle. As a result, dividend policies may fluctuate from time to time. Ans b) Reorder Level This is that level of materials at which a new order for supply of materials is to be placed. In other words, at this level a purchase requisition is made out. This level is fixed somewhere between maximum and minimum levels. Order points are based on usage during time necessary to requisition order, and receive materials, plus an allowance for protection against stock out.The  order point  is reached when inventory on hand and quantities due in are equal to the lead time usage quantity plus the safety   stock quantity. Formula of Re-order Level or Ordering Point: The following two formulas are used for the calculation of  reorder level or point. Ordering point or re-order level = Maximum daily or weekly or monthly usage ? Lead time The above formula is used when usage and lead time are known with certainty; therefore, no safety stock is provided. When safety stock is provided then the following formula will be applicable: Ordering point or re-order level = Maximum daily or weekly or monthly usage ?Lead time + Safety stock Q. 3 Sales Rs. 400, 000 less returns Rs 10, 000, Cost of Goods Sold Rs 300,000, Administration and selling expenses Rs. 20, 000, Interest on loans Rs. 5000, Income tax Rs. 10000, preference dividend Rs. 15,000, Equity Share Capital Rs. 100, 000 @Rs. 10 per share. Find EPS. Sales Rs. 400, 000 less returns Rs 10, 000, Cost of Goods Sold Rs 300,000, Administration and selling expenses Rs. 20, 000, Interest on loans Rs. 5000, Income tax Rs. 10000, preference dividend Rs. 15,000, Equity Share Capital Rs. 100, 000 @Rs. 10 per share. Find EPS. Sales | | |400,000 | | |Less Returns | |10,000 |390,000 | | | | | | | |Less | | | | | |COGS | | |30,000 | | |S | | |20,000 | | |Int on Loan | | |5,000 | | |IT | | |10,000 |325,000 | |Div | | |15,000 | | |ESC | | |100,000 |@ 10/- | |NPAT – Pref Share Div | | | | |No of Shares | | | | | | | | | | |NPAT | | |55,000 | | |less Pref Share Div | |15,000 |40,000 | | | | | | | |EPS | | |40,000 |=Rs. 4/- | | | | |10,000 | | Q. 4 What are the techniques of evaluation of investment? Three steps are involved in the evaluation of an investment: †¢Estimation of cash flows †¢Estimation of the required rate of return (the opportunity cost of capital)   †¢Application of a decision rule for making the choice. The first two steps, discussed in the subsequent chapters, are assumed as given. Thus, our discussion in this chapter is confined to the third step. speifically, we focus on the merits and demerits of various decision rules. Investment decision ruleThe investment decision rules may be referred to as capital budgeting techniques, or investment criteria. A sound appraisal technique should be used to measure the economic worth of an investment project. The essential property of a sound technique is that it should maximize the shareholders’ wealth. The following other characteristics should also be possessed by a sound investment evaluation criterion. †¢ It should consider all cash flows to determine the true pro fitability of the project. †¢ It should provide for an objective and unambiguous way of separating good projects form bad projects. †¢ It should help ranking of projects according to their true profitability. It should recognize the fact that bigger cash flows true profitability. †¢ It should recognize the fact that bigger cash flows are preferable to smaller once and early cash flows are preferable to later ones. †¢ It should help top choose among mutually exclusive projects that project which maximizes the shareholders’ wealth. †¢ It should be a criterion which is applicable to any conceivable investment project independent of other. These conditions will be clarified as we discuss the features of various investment criteria in the following pages. Evaluation criteria A number of investments criteria (or capital budgeting techniques) are in use in proactive. They may be grouped in the following two categories: 1.Discounted cash flow (DCF) criteria à ¢â‚¬ ¢ Net present value (NPV) †¢ Internal rate of return (IIR) †¢ Profitability index (PI) 2. Non-discounted cash flow criteria †¢ Payback period (PB) †¢ Discounted payback period †¢ Accounting rate of return (ARR). Discounted payback is a variation of the payback method. It involves discounted cash flows, but as we shall see later, it is not a true measure of investment profitability. We will show in the following pages that the net present value criterion is the most valid technique of maximizing the shareholders wealth. Problems associated with inadequate working capital Working capital may be regarded as the life blood of business.Working capital is of major importance to internal and external analysis because of its close relationship with the current day-to-day operations of a business. Every business needs funds for two purposes. * Long term   funds are required   to create production facilities through purchase of fixed assets such as plants, ma chineries, lands, buildings & etc * Short term funds are required for the purchase of raw materials, payment of wages, and other day-to-day expenses. . It is other wise known as revolving or circulating capital It is nothing but the difference between current assets and current liabilities. i. e. Working Capital = Current Asset – Current Liability. Businesses use capital for construction, renovation, furniture, software, equipment, or machinery.It is also commonly used to purchase inventory, or to make payroll. Capital is also used often by businesses to put a down payment down on a piece of commercial real estate. Working capital is essential for any business to succeed. It is becoming increasingly important to have access to more working capital when we need it. Q. 5 What are the problems associated with inadequate working capital? A business firm must maintain an adequate level of working capital in order to run its business smoothly. It is worthy to note that both excessi ve and inadequate working capital positions are harmful. Working capital is just like the heart of business. If it becomes weak, the business can hardly prosper and survive.No business can run successfully without an adequate amount of working capital. Danger of inadequate working capital When working capital is inadequate, a firm faces the following problems. Fixed Assets cannot efficiently and effectively be utilized on account of lack of sufficient working capital. Low liquidity position may lead to liquidation of firm. When a firm is unable to meets its debts at maturity, there is an unsound position. Credit worthiness of the firm may be damaged because of lack of liquidity. Thus it will lose its reputation. There by, a firm may not be able to get credit facilities. It may not be able to take advantages of cash discount. Disadvantages of Redundant or Excessive Working Capital 1.Excessive Working Capital means ideal funds which earn no profits for the business and hence the busin ess cannot earn a proper rate of return on its investments. 2. When there is a redundant working capital, it may lead to unnecessary purchasing and accumulation of inventories causing more chances of theft, waste and losses. 3. Excessive working capital implies excessive debtors and defective credit policy which may cause higher incidence of bad debts. 4. It may result into overall inefficiency in the organization. 5. When there is excessive working capital, relations with banks and other financial institutions may not be maintained. 6. Due to low rate of return on investments, the value of shares may also fall. 7.The redundant working capital gives rise to speculative transactions. Disadvantages or Dangers of Inadequate Working Capital 1. A concern which has inadequate working capital cannot pay its short-term liabilities in time. Thus, it will lose its reputation and shall not be able to get good credit facilities. 2. It cannot buy its requirements in bulk and cannot avail of disc ounts, etc. 3. It becomes difficult for the firm to exploit favourable market conditions and undertake profitable projects due to lack of working capital. 4. The firm cannot pay day-to-day expenses of its operations and its creates inefficiencies, increases costs and reduces the profits of the business. 5.It becomes impossible to utilize efficiently the fixed assets due to non-availability of liquid funds. 6. The rate of return on investments also falls with the shortage of working capital. Disadvantages or Dangers of Inadequate or Short Working Capital †¢ Can’t pay off its short-term liabilities in time. †¢ Economies of scale are not possible. †¢ Difficult for the firm to exploit favourable market situations †¢ Day-to-day liquidity worsens †¢ Improper utilization the fixed assets and ROA/ROI falls sharply Q. 6 What is leverage? Compare and Contrast between operating Leverage and financial leverage (10 Marks) ‘Leverage’ is the action of a lever or the mechanical advantage gained by it; it also means ‘effectiveness’ or ‘power’.The common interpretation of leverage is derived from the use or manipulation of a tool or device termed as lever, which provides a substantive clue to the meaning and nature of financial leverage. When an organization is planning to raise its capital requirements (funds), these may be raised either by issuing debentures and securing long term loan 0r by issuing share-capital. Normally, a company is raising fund from both sources. When funds are raised from debts, the Co. investors will pay interest, which is a definite liability of the company. Whether the company is earning profits or not, it has to pay interest on debts. But one benefit of raising funds from debt is that interest paid on debts is allowed as deduction for income tax. When funds are raised by issue of shares (equity) , the investor are paid dividend on their investment. Dividends are paid only when th e Company is having sufficient amount of profit. In case of loss, dividends are not paid. But dividend is not allowed as deduction while computing tax on the income of the Company. In this way both way of raising funds are having some advantages and disadvantages. A Company has to decide that what will be its mix of Debt and Equity, considering the liability, cost of funds and expected rate of return on investment of fund. A Company should take a proper decision about such mix, otherwise it will face many financial problems.For the purpose of determination of mix of debt and equity, leverages are calculated and analyzed. Concept of Financial Leverage Leverage may be defined as the employment of an asset or funds for which the firm pays a fixed cost or fixed return. The fixed cost or return may, therefore be thought of as the full annum of a lever. Financial leverage implies the use of funds carrying fixed commitment charge with the objective of increasing returns to equity sharehold ers. Financial leverage or leverage factor is defined, as the ratio of total value of debt to total assets or the total value of the firm. For example, a firm having a total value of Rs. ,00,000 and a total debt of Rs. 1,00,000 would have a leverage factor of 50 percent. There are difficult measures of leverage such as. i. The ratio of debt to total capital ii. The ratio of debt to equity iii. The ratio of net operating income (earning before interest and taxes) to fixed’ charges) The first two measures of leverage can be expressed either in book v8lue or market value the debt of equity ratio as a measure of financial leverage is more popular in practice. â€Å" Risk & Financial Leverage: Effects of financial Leverage:  The use of leverage results in two obvious effects: i. Increasing the shareholders earning under favorable economic conditions, and ii.Increasing the financial risk of the firm. Suppose there are two companies each having a Rs. 1,00,000 capital structure. O ne company has borrowed half of its investment while the other company has only equity capital: Both earn Rs. 2,00,000 profit. The ratio of interest on the borrowed capital is 10%and the rate of corporate tax 50%. Let us calculate the effect of financial leverage, both in the shareholders earnings and the Company’s financial risk in these two companies. (a) Effect of Leverage on Shareholders Earnings: |  |   |  |Company A |  |Company B | | | | |Rs. | |Rs. |  |Profit before Interest and Taxes | |2,00,000 | |2,00,000 | |  |Equity | |10,00,000 | |5,00,000 | |  |Debt | |—- | |5,00,000 | |  |Interest (10%) | |—- | |50,000 | |  |Profit after interest but before Tax | |2,00,000 | |1,50,000 | |  |Taxes @ 50% | |1,00,000 | |75,000 | Rate of return on Equity of Company A Rs. 1,00,000/Rs. 10,00,000 = 10% Rate of return on Equity of Company B Rs. 75,000/Rs. 5,00,000 = 15% The above illustration points to the favorable effect of the leverage factor on ear nings of shareholders. The concept of leverage is 5 if one can earn more on the borrowed money that it costs but detrimental to the man who fails to do so far there is such a thing as a negative leverage i. e. borrowing money at 10% to find that, it can earn 5%. The difference comes out of the shareholders equity so leverage can be a double-edged sword. b) Effect of Leverage on the financial risk of the company:  Financial risk broadly defined includes both the risk of possible insolvency and the changes in the earnings available to equity shareholders. How does the leverage factor leads to the risk possible insolvency is self-explanatory. As defined earlier the inclusion of more and more debt in capital structure leads to increased fixed commitment charges on the part of the firm as the firm continues to lever itself, the changes of cash insolvency leading’ to legal bankruptcy increase because the financial ‘charges incurred, by the firm exceed the expected earnings. Obviously this leads to fluctuations in earnings’ available to the equity shareholders. Relationship: Financial and Operating leverage:Relationship between financial and operating leverage:  In business terminology, leverage is used in two senses: Financial leverage & Operating Leverage Financial leverage:  The effect which the use of debt funds produces on returns is called financial leverage. Operating leverage:  Operating leverage refers to the use of fixed costs in the operation of the firm. A firm has a high degree of operating leverage if it employs a greater amount of fixed costs. The degree of operating leverage may be defined as the percentage change in profit resulting from a percentage change in sales. This can be expressed as: = Percent Change in Profit/Percent Change in SalesThe degree of financial leverage is defined as the percent change in earnings available to common shareholders that is associated with a given percentage change in EBIT. Thus, operatin g leverage affects EBIT while financial leverage affects earnings after interest and taxes the earnings available to equity shareholders. For this reason operating leverage is sometimes referred to as first stage leverage and financial leverage as second stage leverage. Therefore, if a firm uses a considerable amount of both operating leverage and financial leverage even small changes in the level of sales will produce wide fluctuations in earnings per share (EPS).The combined effect of both these types of leverages is after called total leverage which, is closely tied to the firm’s total risk. MB0046 -Marketing Management Assignment Set – 1 Q. 1 ]a. Explain the different micro-environmental forces with examples. Forces in the micro environment [pic] 1 The Company Remember, in the previous unit we discussed about marketing mix and marketing plan. Safe Express, a leader in the supply chain management solution wants to hold its number one position in the US $ 90 billion Indian logistics market. The company plans to expand its service areas in the coming months. To meet the targets of the marketing plan, other departments of safe express also expanding their horizon.The Company is coming out with logistics parks in different cities; plans to hold seven million square feet of warehousing capacity in the next three years and invest Rs 10 billion in three years to meet those targets. The above example shows that the company’s marketing plan should be supported by the other functional departments also. 2 Intermediaries Marketing intermediaries: These are firms which distribute and sell the goods of the company to the consumer. Marketing intermediaries play an important role in the distribution, selling and promoting the goods and services. Stocking and delivering, bulk breaking, and selling the goods and services to customer are some of the major functions carried out by the middlemen.Retailers, wholesalers, agents, brokers, jobbers and carry for ward agents are few of the intermediaries. Retailers are final link between the company and the customers. Their role in the marketing of product is increasing every day. 3 Publics These are microenvironment groups, which help a company to generate the financial resources, creating the image, examining the companies’ policy and developing the attitude towards the product. We can identify six types of publics 1. Financial publics influence the company’s ability to obtain funds. For example, Banks, investment houses and stockholders are the major financial publics. 2. Media publics carry news and features about the company e. g.Deccan Herald 3. Advertisement regulation agencies, telecom regulation agency( TRAI), and insurance regulation agency(IRDA) of the government 4. Citizen action groups: Formed by the consumer or environmental groups. For example, people for ethical treatment of animals (PETA) or Greenpeace. 5. General publics: a compa